The eighth Annual Pezcoller Symposium, entitled Genomic Instability and Immor- tality in Cancer, was held in Trento, Italy, June 17-19, 1996 and was focused on the clari- fication of the mechanisms of genetic instability, a characteristic of neoplastic cells which also determines tumor progression, and immortality consequent to the lack of susceptibil- ity to mechanisms of maturations, senescence and/or apoptosis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to mutational lability, changes in DNA repair capa- bilities,...