Kategoria BISAC: Science >> Research & Methodology

This volume is part of a continuing Electroanalytical Chemistry Series designed to provide authoritative reviews on recent developments and applications of well-established techniques in the field of electroanalytical chemistry. Electroanalytical techniques are used in such diverse areas as electro-organic synthesis, fuel cell studies, and radical ion formation. Each volume provides the necessary background and starting point for graduate students undertaking related research projects and is of special interest to practicing analytical chemists concerned with electroanalytical techniques....

Fascinating biology occurs at epithelial interfaces, whether between organism and environment or within body compartments, and many diseases inflicting huge personal and societal burdens result from dysfunction of epithelial systems, e.g., carcinomas. Epithelial cell cultures have been an integral and crucial part of the biomedical research enterprise, adding unique capabilities and enabling mechanistic approaches. In the past decade there have been many research advances, such as directed differentiation of embryonic stem cells and induced pluripotent stem cells, robotic high throughput...

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across...

A great deal of confusion and uncertainty over genotoxic impurity (GTI) identification, assessment, and control exists in the pharmaceutical industry today. Pharmaceutical Industry Practices on Genotoxic Impurities strives to facilitate scientific and systematic consensus on GTI management by presenting rationales, strategies, methods, interpretations, practices, and case studies from the pharmaceutical industry. Featuring the contributions of industry leaders from nine major pharmaceutical companies, this authoritative text:

• Explores the safety, quality, and...

The second edition of Biological Aging: Methods and Protocols expands upon the previous edition with current, detailed, useful and promising methods currently available to study aging. With new chapters on protocols that detail aging cell culture as well as many more contemporary approaches such as nuclear transfer, microarray and proteomics technologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible...

"Smart, funny, clear, unflinching: Ben Goldacre is my hero." --Mary Roach, author of Stiff, Spook, and Bonk

We like to imagine that medicine is based on evidence and the results of fair testing and clinical trials. In reality, those tests and trials are often profoundly flawed. We like to imagine that doctors who write prescriptions for everything from antidepressants to cancer drugs to heart medication are familiar with the research literature about these drugs, when in reality much of the research is hidden from them by drug...

Diverse molecular, cellular, and environmental events must all come together to allow the successful formation of secondary cancers, metastases. The second edition of Metastasis Research Protocols, brings together updated versions of the seminal technique that were presented in the first edition and also includes new techniques that have recently been shown to be important in illuminating the processes underlying this important area of biology. Volume 2 presents techniques applicable at the level of living cells and tissues, and presents methodologies applicable to cell...

The rapid progress of neuroscience in the last decade can be largely attributed to significant advances in neuroethology, a branch of science that seeks to understand the neural basis of natural animal behavior. Novel approaches including molecular biological techniques, optical recording methods, functional anatomy, and informatics have brought drastic changes in how the neural systems underlying high-level behaviors such as learning and memory are described. This book introduces recent research techniques in neuroethology, with diverse topics involving nematodes, insects, and vertebrates...

Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle, and Albert Einstein all made groundbreaking contributions to their fields--but each also stumbled badly. Darwin's theory of natural selection shouldn't have worked, according to the prevailing beliefs of his time. Lord Kelvin gravely miscalculated the age of the earth. Linus Pauling, the world's premier chemist,...

Methods in Stream Ecology, Second Edition, provides a complete series of field and laboratory protocols in stream ecology that are ideal for teaching or conducting research.

This updated edition reflects recent advances in the technology associated with ecological assessment of streams, including remote sensing. In addition, the relationship between stream flow and alluviation has been added, and a new chapter on riparian zones is also included.

The book features exercises in each chapter; detailed instructions, illustrations, formulae, and data sheets for in-field...