Assessing Ocular Toxicology in Laboratory Animals

ISBN-13: 9781627031639 / Angielski / Twarda / 2012 / 322 str.

Andrea B. Weir; Margaret Collins

Opis

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Recenzje

From the reviews:

"This book is the second volume in the first edition of the Molecular and Integrative Toxicology collection. ... The text is very well illustrated, with 45 black-and-white and 75 color plates as well as 36 tables. ... This book provides an excellent survey of nonclinical laboratory practices in ocular toxicology. I consider it to be a valuable reference for all nonclinical research toxicologists, pharmacologists, veterinarians and laboratory animal care technicians with an interest in ophthalmology." (Alan C. Katz, International Journal of Toxicology, Vol. 32 (5), 2013)

"The book is easy to read with many clear colour photographs and background information ... and is supported by a wealth of literature references. ... This is certainly a book that earns the right to be in toxicology libraries and will provide a valuable source of information for ophthalmologists, pathologists and toxicologists." (David R. Jones, BTS Newsletter - The British Toxicology Society, Issue 43, Winter, 2013)

Spis treści

Comparative Ocular Anatomy in Commonly Used Laboratory Animals.- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques.- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals.- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals.- Toxicologic Pathology of the Eye:  Histologic Preparation and Alterations of the Anterior Segment.- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment.- Nonclinical Regulatory Aspects for Ophthalmic Drugs.- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug.