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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation
ISBN: 9783642246319 / Angielski / Twarda / 130 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of... In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-conta... |
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402,53 |
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Pharmaceutical Competitive Intelligence for the Regulatory Affairs Professional
ISBN: 9781461436812 / Angielski / Miękka / 82 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry. It provides an overview of processes that the regulatory affairs professional must take into account when evaluating data impacting product-based risk evaluations. These apply particularly to evaluations that focus on outputs such as regulatory approval, or the commercial impact of product labeling on the sales forecast over a limited timeframe. The Brief also provides an overview of intellectual property assessment that can impact a product's lifespan on the market...
This Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry. It provides an overview...
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261,63 |
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Tetramer Stability and Functional Regulation of Tumor Suppressor Protein P53
ISBN: 9784431541349 / Angielski / Twarda / 74 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein-protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the...
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric struc...
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201,24 |
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Single-Stranded DNA Binding Proteins: Methods and Protocols
ISBN: 9781627030311 / Angielski / Twarda / 259 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The genomes of cellular organisms are organized as double-stranded DNA, a structure that must be unwound to provide DNA replication, recombination, and repair machinery access to genomic information. However, DNA unwinding comes with inherent risks to genome stability. To help mediate these risks, bacterial, archael, and eukaryotic cells have evolved protective ssDNA-binding proteins (SSBs) that bind ssDNA with high affinity and specificity. SSBs also aid genome metabolic processes through direct interactions with key proteins in genome maintenance enzymes. Single-Stranded DNA Binding... The genomes of cellular organisms are organized as double-stranded DNA, a structure that must be unwound to provide DNA replication, recombination,... |
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402,53 |
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Protein Supersecondary Structures
ISBN: 9781627030649 / Angielski / Twarda / 320 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Super secondary structure(SSS) helps to understand the relationship between primary and tertiary structure of proteins. In Protein Supersecondary Structure: Methods and Protocols expert researchers in the field detail the usefulness of the study of super secondary structure in different areas of protein research. This is done through four main studies SSS representation, SSS prediction, SSS and protein folding, and other application of SSS concept to protein biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions... Super secondary structure(SSS) helps to understand the relationship between primary and tertiary structure of proteins. In Protein Supersecondar... |
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603,81 |
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Key Elements in Polymers for Engineers and Chemists: From Data to Applications
ISBN: 9781926895802 / Angielski / Twarda / 454 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book provides comprehensive coverage on the latest developments of research in the ever-expanding area of polymers and advanced materials and their applications to broad scientific fields including physics, chemistry, biology, and materials. It presents physical principles in explaining and rationalizing polymeric phenomena. Featuring classical topics that are conventionally considered as part of chemical technology, the book covers the chemical principles from a modern point of view. It analyzes theories to formulate and prove the polymer principles and offers future outlooks on...
This book provides comprehensive coverage on the latest developments of research in the ever-expanding area of polymers and advanced materials and the...
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cena:
587,73 |
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The Story of N: A Social History of the Nitrogen Cycle and the Challenge of Sustainability
ISBN: 9780813554389 / Angielski / Twarda / 260 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In The Story of N, Hugh S. Gorman analyzes the notion of sustainability from a fresh perspective--the integration of human activities with the biogeochemical cycling of nitrogen--and provides a supportive alternative to studying sustainability through the lens of climate change and the cycling of carbon. It is the first book to examine the social processes by which industrial societies learned to bypass a fundamental ecological limit and, later, began addressing the resulting concerns by establishing limits of their own The book is organized into three parts. Part I, "The Knowledge...
In The Story of N, Hugh S. Gorman analyzes the notion of sustainability from a fresh perspective--the integration of human activities with the ...
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259,58 |
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RNA Interference from Biology to Therapeutics
ISBN: 9781461447436 / Angielski / Twarda / 340 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize...
The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest fr...
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885,61 |
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Functional Phthalocyanine Molecular Materials
ISBN: 9783642262661 / Angielski / Miękka / 325 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Phthalocyanines exhibit intriguing physic-chemical properties that render them important as a class of molecular functional materials. In addition to their tra- tional industrial applications as dyes and pigments, more recently their use as the organic semiconductors, photodynamictherapy medicines, non-linear optical ma- rials, catalysts for the photo oxidation, optical recording materials, and gas sensors attracts great research interests in these tetrapyrrole species. As manifested by the rapidly increasing number of related scienti?c publications in recent years, great progress has been...
Phthalocyanines exhibit intriguing physic-chemical properties that render them important as a class of molecular functional materials. In addition to ...
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1207,67 |
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Investigation of Reactions Involving Pentacoordinate Intermediates: The Mechanism of the Wittig Reaction
ISBN: 9783642320446 / Angielski / Twarda / 231 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this thesis, the author outlines the discovery of an effect common to representative examples of all Li salt-free Wittig reactions. The implications of such a universally applicable effect are that all such Wittig reactions occur through the same mechanism.
In this thesis, the author outlines the discovery of an effect common to representative examples of all Li salt-free Wittig reactions. The implication...
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402,53 |
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Introductory Essays
ISBN: 9783642663970 / Angielski / Miękka / 156 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This set of essays was given as lectures at the 4th Waterloo International Summer School on Nuclear Magnetic Resonance held in June 1975 at the University of Water loo. The school was sponsored by the National Research Council of Canada and by the Canadian Association of Physicists. These Contributions are introductory and were not intended to be review papers. For valuable help, I would like to thank R. S. Hallsworth, D. W. Nicoll, and R. T. Thompson. M.M.Pintar Table of Contents A Guide to Relaxation Theory. By A. G. Redfield .................... 1 Thermodynamics of Spin Systems in Solids....
This set of essays was given as lectures at the 4th Waterloo International Summer School on Nuclear Magnetic Resonance held in June 1975 at the Univer...
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402,53 |
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The Chemistry and Technology of Cellulosic Copolymers
ISBN: 9783642677090 / Angielski / Miękka / 352 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Many excellent volumes have been written on the chemistry of cellulose and its derivatives. Judging by the number of conferences which have been assembled to deal with the topic, cellulose and its derivatives continue to arouse great scientific interest. Matching this interest has been the development in copolymer science and technology. In both instances the driving force has been the search for products having useful, new or interesting properties. It appeared inevitable that these two concepts would be brought together at some time in the research and development of cellulosic copolymers....
Many excellent volumes have been written on the chemistry of cellulose and its derivatives. Judging by the number of conferences which have been assem...
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402,53 |
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Supramolecular Structure and Function
ISBN: 9783642709074 / Angielski / Miękka / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. During the past decade we have witnessed not only an increase in knowledge of the "traditional" biophysical problems, but also an understanding of the molecular basis of various biological phenomena. The principles and methods of biophysics now provide an underpin ning of all of the basic biosciences and are the rational language for discussion between scientists of different disciplines. The International School on Biophysics Supramolecular Structure and Function held in Dubrovnik in September 1984 had as its goal to provide comprehensive discussions on a large number of subjects both for...
During the past decade we have witnessed not only an increase in knowledge of the "traditional" biophysical problems, but also an understanding of the...
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402,53 |
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Natural Product Chemistry: Proceedings of the First International Symposium and Pakistan-U.S. Binational Workshop, Karachi, Pakistan
ISBN: 9783642714276 / Angielski / Miękka / 564 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The First International Symposium and Pakistan-U.S. Binational Workshop on Natural Product Chemistry represents the first international conference ever to be organised in Pakistan on chemistry. For many years I had aspired to organise such a con- ference, and finally when it materialised in February 1984, it brought together the very best in the field. The result was as expected - a most stimulating series of lectures and discussions, all of which were recorded on videotape for circulation to uni- versities and research organisations in Pakistan. The fields covered during the Symposium...
The First International Symposium and Pakistan-U.S. Binational Workshop on Natural Product Chemistry represents the first international conference eve...
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402,53 |
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Surfactants in Consumer Products: Theory, Technology and Application
ISBN: 9783642715471 / Angielski / Miękka / 548 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In to days market, custom formulated surfactants are offered for a wide range of applications. The need for surfactants in detergents, cleaning agents, cosmetics & toiletries is second only to an expanding demand in industrial applications. But even within the non-industrial areas the demands have undergone significant changes in recent years. For example, washing and cleaning temperatures have substantially decreased with increased energy conservation attitudes, and more stringent regulatory requirements in the area of ecology and toxicology are leading to new product profiles. New...
In to days market, custom formulated surfactants are offered for a wide range of applications. The need for surfactants in detergents, cleaning agents...
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402,53 |
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Petroleum Hydrocarbons
ISBN: 9783642717390 / Angielski / Miękka / 256 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Analyses data on the composition, structure and formation of various petroleum hydrocarbons: the alkanes, cycloalkanes and arenes. Attention is paid to biological markers, com- pounds that may have preserved the main structural features of the original biogenic molecules. Concepts of chemical classification of crude oils are reviewed with respect to the molecular mass distribution of biological markers, and the genesis and chemical evolution of petroleum hydrocarbons are discussed.
Analyses data on the composition, structure and formation of various petroleum hydrocarbons: the alkanes, cycloalkanes and arenes. Attention is paid t...
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201,24 |
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Biologische Restabfallbehandlung: Methoden, Anlagen Und Perspektiven
ISBN: 9783642721663 / Niemiecki / Miękka / 239 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Zur biologischen Behandlung von Restabfall werden verschiedene Verfahren eingesetzt. Je nach Menge, Art und Zusammensetzung des Restm lls und entsprechend abfallwirtschaftlicher Zielvorgaben k nnen geeignete Standardaggregate und diverse biologische Behandlungssysteme definiert und miteinander kombiniert werden. Bei den Verfahren f r die mechanisch-biologische Restabfallbehandlung gibt es zur Zeit keinen bundesweit anerkannten Stand der Technik. Die bisher geplanten und realisierten Anlagen unterscheiden sich hinsichtlich der Zielsetzung (z.B. biologische Stabilisierung oder biologische...
Zur biologischen Behandlung von Restabfall werden verschiedene Verfahren eingesetzt. Je nach Menge, Art und Zusammensetzung des Restm lls und entsprec...
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206,88 |
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Cellulose Hydrolysis
ISBN: 9783642725777 / Angielski / Miękka / 198 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Recent economic trends, especially the worldwide decline in oil prices, and an altered political climate in the United States have combined to bring about major reductions in research on renewable energy resources. Yet there is no escaping the "facts of life" with regard to these resources. The days of inexpensive fossil energy are clearly numbered, the credibility of nuclear energy has fallen to a new low, and fusion energy stands decades or more from practical realization. Sooner than we may wish, we will have to turn to renewable raw materials - plant "biomass" and, especially, wood - as...
Recent economic trends, especially the worldwide decline in oil prices, and an altered political climate in the United States have combined to bring a...
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201,24 |
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Facets of Modern Biogeochemistry: Festschrift for E.T. Degens
ISBN: 9783642739804 / Angielski / Miękka / 433 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Scientists who have had the opportunity of being associated with Professor Egon T. Degens, to whom this Festschrift is devoted, have been influenced by his ideas on subjects as varied as: extraterrestrial organic matter, origin of life, evolution of organisms, isotope biogeochemistry down to more imminent ones such as the carbon cycle and its implications on climate. This variety is also reflected in the papers in the present volume contributed by colleagues who have known Egon or have worked with him. Egon Theodor Degens was born on April 16, 1928 at Inden, Germany and had his education in...
Scientists who have had the opportunity of being associated with Professor Egon T. Degens, to whom this Festschrift is devoted, have been influenced b...
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402,53 |
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Natural Products Chemistry III
ISBN: 9783642740190 / Angielski / Miękka / 374 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Natural product chemistry has undergone an explosive growth during the latter half of the current century. This has been brought about by a number of factors. One of these has been the growing number of sub stances from natural sources which display interesting pharmacological activities. These include antibiotics, anti-tumor agents, immunostimu lants, drugs affecting the cardiovascular and central nervous systems, analgesics etc. Another factor has been the improvements made in the technology of isolation processes which includes the development of such techniques as high pressure liquid...
Natural product chemistry has undergone an explosive growth during the latter half of the current century. This has been brought about by a number of ...
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cena:
603,81 |
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