Kategoria BISAC: Science >> Life Sciences - Biochemistry

Antisense-based drugs are part of a growing number of pharmaceutical and biotech programs to treat diseases including cancer, diabetes, and ALS. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide from the safety assessment to clinical experience with antisense oligonucleotides.

- Examines principles and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides
- Reviews fundamentals and provides guidelines for scientists in drug design and discovery to...

Accurate assessment of human drug toxicity is a major challenge in the pharmaceutical industry. Drug metabolism and toxicology are two scientific disciplines that traditionally have been considered independently. For instance, in drug development, drug candidates are evaluated for properties in these two disciplines in different departments. It is now becoming apparent that the two disciplines are closely related in terms of safety evaluation.

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity provides a comprehensive and up-to-date coverage of the relationship...

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington s disease and from inflammation to sickle cell anaemia.

The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed,...

Nanomedicines and nanopharmacology is a rapidly developing and evolving field with new techniques and applications under constant development. This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine. Providing an understanding of the relationship of nanocarrier, drug and targetting moieties and physico-chemical properties, this title will provide an accurate and current representation of the field by addressing the promises, prospects and pitfalls of nanomedicine. Covering a wide range of areas in...

Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.

Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and...

Trees that are indispensably supportive to human life pose a formidable challenge to breed them to suit to human needs. From soft drinks to breweries to beverages to oil to tires, the value added products from trees give a spectrum of products to human kind. While attempts to tap these resources through conventional breeding are underway, the quick and elegant way of manipulating the genetic systems at the genome level is an essential chapter of modern science. Books featuring genomics of tree crops are few, and genomics is such a science that changes rapidly. Genomics of Tree Crops...

The second edition covers a wide range of protein-protein interaction detection topics. Protein-Protein Interactions: Methods and Applications focuses on core technological platforms used to study protein-protein interactions and cutting-edge technologies that reflect recent scientific advances and the emerging focus on therapeutic discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of necessary materials and reagents, step-by-step laboratory protocols, and tips on...