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Human Medical Research: Ethical, Legal and Socio-Cultural Aspects
ISBN: 9783034803892 / Angielski / Twarda / 188 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Medical research involving human subjects has contributed to considerable advancements in our knowledge, and to medical benefits. At the same time the development of new technologies as well as further globalisation of medical research raises questions that require the attention of researchers from a range of disciplines. This book gathers the contributions of researchers from nine different countries, who analyse recent developments in medical research from ethical, historical, legal and socio-cultural perspectives. In addition to reflections on innovations in science such as genetic... Medical research involving human subjects has contributed to considerable advancements in our knowledge, and to medical benefits. At the same time ... |
cena:
605,23 |
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Ethical Challenges in Genomics Research: A Guide to Understanding Ethics in Context
ISBN: 9783642236983 / Angielski / Twarda / 234 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. New developments in science and technology have resulted in shifting ethical challenges in many areas including in genomics research. This book enables those who are involved in genomics research, whether as researcher, participant or policy maker, to understand the ethical issues currently developing in this field and to participate actively in these important debates. A clear account is given of how science and technology are outstripping the capacity of previous ethical regulations to cope with current issues, together with practical illustrations of possible ways forward. Key ethical... New developments in science and technology have resulted in shifting ethical challenges in many areas including in genomics research. This book ena... |
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645,58 |
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Advances in Yersinia Research
ISBN: 9781461435600 / Angielski / Twarda / 367 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book is a collection of articles written by prominent scientists who gathered in the city of Recife, Brazil, 23-27 October 2010, celebrating the 10th International Symposium on Yersinia. The event is held every four years in a different country and for the Yersinia 2010, an interesting and updated program covering advances in research in Yersiniae was organized. The major advances achieved over the past four years since the last symposium held in Lexington, USA in 2006 were divided into eight chapters: Epidemiology, Clinical, Diagnostic and Therapeutic aspects; Ecology and Modeling;...
This book is a collection of articles written by prominent scientists who gathered in the city of Recife, Brazil, 23-27 October 2010, celebrating the ...
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cena:
887,69 |
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Mitochondrial Oxidative Phosphorylation: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology
ISBN: 9781461435723 / Angielski / Twarda / 372 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are...
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur i...
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cena:
806,99 |
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Signaling Pathways and Molecular Mediators in Metastasis
ISBN: 9789400725577 / Angielski / Twarda / 378 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a...
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pa...
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cena:
605,23 |
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Genetically Encoded Functional Indicators
ISBN: 9781627030137 / Angielski / Twarda / 169 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume brings together expert contributors to present the development of recent genetic techniques that allow for generating genetically encoded activity sensors in order to investigate neuronal activity. Each chapter describes a specific sensor and its utilization to study neuronal activity in a particular way.
This volume brings together expert contributors to present the development of recent genetic techniques that allow for generating genetically encoded ...
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cena:
403,47 |
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Phosphoinositides I: Enzymes of Synthesis and Degradation
ISBN: 9789400730113 / Angielski / Twarda / 356 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid...
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turnin...
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cena:
605,23 |
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From Nucleic Acids Sequences to Molecular Medicine
ISBN: 9783642274251 / Angielski / Twarda / 654 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine. Includes numerous illustrations.
Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medi...
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cena:
806,99 |
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Mortalin Biology: Life, Stress and Death
ISBN: 9789400730267 / Angielski / Twarda / 342 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book presents research on the stress protein mortalin and its essential role in life, stress response and death. Coverage includes mortalin's discovery, structure, evolutionary conservation, function and signal transduction in different organisms.
This book presents research on the stress protein mortalin and its essential role in life, stress response and death. Coverage includes mortalin's dis...
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cena:
605,23 |
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Brain, Behavior and Epigenetics
ISBN: 9783642268328 / Angielski / Miękka / 320 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but...
Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are num...
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cena:
806,99 |
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Arrestins - Pharmacology and Therapeutic Potential
ISBN: 9783642411984 / Angielski / Twarda / 447 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners. This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing ... |
cena:
1210,50 |
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Genetic and Molecular Epidemiology of Multiple Myeloma
ISBN: 9781461446590 / Angielski / Twarda / 125 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multiple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance. The exact mechanism of the transition from MGUS to...
Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, an...
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cena:
605,23 |
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Genome-Wide Prediction and Analysis of Protein-Protein Functional Linkages in Bacteria
ISBN: 9781461447047 / Angielski / Miękka / 60 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Using genome sequencing, one can predict possible interactions among proteins. There are very few titles that focus onprotein-protein interaction predictions in bacteria. The authors willdescribe these methods and further highlight its use to predict various biological pathways andcomplexity of the cellular response to various environmental conditions. Topics include analysis of complex genome-scale protein-protein interaction networks, effects of reference genome selection on prediction accuracy, and genome sequence templates to predict protein function."
Using genome sequencing, one can predict possible interactions among proteins. There are very few titles that focus onprotein-protein interaction pred...
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cena:
201,56 |
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Microarrays in Diagnostics and Biomarker Development: Current and Future Applications
ISBN: 9783642282027 / Angielski / Twarda / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards "nanoarrays," which is expected to have great...
Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic a...
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cena:
605,23 |
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Phosphoinositides II: The Diverse Biological Functions
ISBN: 9789400730144 / Angielski / Twarda / 460 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid...
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turnin...
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cena:
887,69 |
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RNA and Cancer
ISBN: 9783642316586 / Angielski / Twarda / 245 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling between transcription and splicing. Three subsequent chapters describe in detail cancer-associated...
In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple,...
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cena:
685,93 |
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Ten Years of Progress in Gw/P Body Research
ISBN: 9781461451068 / Angielski / Twarda / 276 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan's group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple...
GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan's group in 2002. These bodies are now known to be active cytoplasmic f...
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cena:
605,23 |
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Biobanking in the Era of the Stem Cell: A Technical and Operational Guide
ISBN: 9781615044726 / Angielski / Miękka / 82 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Working with the National Institute of Mental Health (NIMH), the Rutgers Cell and DNA Repository (RUCDR) has begun banking iPSC source cells and converting those source cells into iPSC for distribution to the scientific community. This book provides detailed protocols for reprogramming either fibroblasts with retroviral vectors or cryopreserved lymphocytes with Sendai viral vectors.
Working with the National Institute of Mental Health (NIMH), the Rutgers Cell and DNA Repository (RUCDR) has begun banking iPSC source cells and conve...
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cena:
192,10 |
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Triple-Helical Nucleic Acids
ISBN: 9781461284543 / Angielski / Miękka / 360 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic...
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacula...
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cena:
605,23 |
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Genetic Research in Psychiatry: "2. Münchner Genetikgespräche" September 12 - 15, 1991 C.I.N.P. President's Workshop
ISBN: 9783642467646 / Angielski / Miękka / 267 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Major and exciting advances in psychiatric genetics were discussed at a 3-day international workshop. The internationally renowned editors assembledan impressive list of specialists, all of whom are leading in their subject. Reviews and short articles which stress special problems or new research results have been brought together in this book, also including intensive discussions of the different topics. Much of the material covers the application of molecular genetics in major psychoses, Alzheimer's dementia or preclinical research. However, the problems of diagnostic features or...
Major and exciting advances in psychiatric genetics were discussed at a 3-day international workshop. The internationally renowned editors assembledan...
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cena:
403,47 |
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