Mortalin Biology: Life, Stress and Death

ISBN-13: 9789400730267 / Angielski / Twarda / 2012 / 342 str.

Opis

The phrase Life, stress and death connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume Mortalin Biology: Life, Stress and Death is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas of mortalin research throw light on its multi-functionality, potentials for biotechnology, diagnostics and therapeutic values. Avenues of mortalin biology, yet unexplored, hold immense promises for future, and reading this volume provides an easy, enthusiastic and energetic head-on start.

Spis treści

Contributors.- Foreword.- Preface.- Section 1: Structure and Function of Mortalin.-  1. Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer.-  2. Mortalin’s Machinery.-  3. The Role of Mortalin in Iron Homeostasis .-  4. Functional Characteristics of Mortalin.- Section 2:  Mortalin in Evolution2 Deocaris.-  5.  Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis .-  6. Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes  .-  7. Mortalin and Stem Cells: A Study from Planarians.-  Section 3: Mortalin in Health and Disease.-  8. Mortalin in Cell Protection from Immune Attack .-  9. Mortalin in Neurological Diseases.-  10. Loss of Mortalin Function in Parkinson’s Disease – Supporting the Mitochondrial Pathway of Neurodegeneration.-  11. Hsp75/mortalin and Protection from Ischemic Brain Injury.- 12. Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders.-  13. Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis.-  Section 4:  Mortalin and Cancer.-  14. The Many Faces of Mortalin and Tid1.-  15. Mortalin: A Positive Regulator of Centrosome Duplication and Amplification.-  16. Mortalin Expression in Normal and Neoplastic Tissues .-  17. Mortalin - p53 Interaction as A Target for Liver Cancer Therapy.-  18. Mortalin Targeting Gadgets for Cancer Therapy.- Section 5:  Mortalin Based Technologies.-  19. Cell Internalizing Anti-Mortalin Antibody for Generation of Illuminating MSCs for Long-Term in vitro and in vivo Tracking.-  20. Mortalin Staining Pattern as A Reporter for Cell Based Anti-Cancer Drug Screening.-  21. Cell Internalizing Anti-Mortalin Antibody as a Nanocarrier.