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Microdialysis in Drug Development
ISBN: 9781489996213 / Angielski / Miękka / 340 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.
A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacologic...
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cena:
442,79 |
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Genomic Instability and Cancer Metastasis: Mechanisms, Emerging Themes, and Novel Therapeutic Strategies
ISBN: 9783319121352 / Angielski / Twarda / 247 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and...
Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support can...
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cena:
402,53 |
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Molecular Therapies of Cancer
ISBN: 9783319132778 / Angielski / Twarda / 488 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Molecular Therapies of Cancer sets out to comprehensively cover the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is a huge literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles with only superficial connections to each other. There is a lack of comprehensive and systematic text on the topic of molecular terapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal...
Molecular Therapies of Cancer sets out to comprehensively cover the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashio...
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cena:
603,81 |
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Electric Cell-Substrate Impedance Sensing and Cancer Metastasis
ISBN: 9789400793804 / Angielski / Miękka / 260 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology,...
Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigati...
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cena:
603,81 |
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Novel Apoptotic Regulators in Carcinogenesis
ISBN: 9789400794931 / Angielski / Miękka / 300 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically...
Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally desi...
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cena:
603,81 |
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Mouse as a Model Organism: From Animals to Cells
ISBN: 9789400796096 / Angielski / Miękka / 165 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in...
Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the p...
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cena:
603,81 |
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Obesity: A Multidisciplinary Approach (Clinics Collections)
ISBN: 9780323359627 / Angielski / Miękka / 1 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Clinics Collections: Obesity draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, endocrinologists, pediatricians, gastroenterologists, nurses, and other healthcare professionals, with practical clinical advice and insights on this highly prevalent disease and its comorbidities. Clinics Collections: Obesity guides readers on how to apply current primary research findings on obesity to everyday practice to help overcome challenges and complications, keep up with new and improved treatment... Clinics Collections: Obesity draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including gen... |
cena:
190,96 |
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Bovine Clinical Pharmacology, an Issue of Veterinary Clinics of North America: Food Animal Practice: Volume 31-1
ISBN: 9780323356688 / Angielski / Twarda / 1 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This issue of Veterinary Clinics of North America: Food Animal Practice is guest edited by Dr. Mike Apley on the topic of Bovine Therapeutics. Article subject areas include: Interpretation of bovine susceptibility, Pain control in cattle, Mastitis, Bovine respiratory disease, Enteric disease, Central nervous system disease, Pinkeye, Genitourinary Problems, Musculoskeletal Problems, and the use of metrics to evaluate therapeutic evidence.
This issue of Veterinary Clinics of North America: Food Animal Practice is guest edited by Dr. Mike Apley on the topic of Bovine Therapeutics. Article...
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cena:
313,40 |
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A Laboratory Guide to Glycoconjugate Analysis
ISBN: 9783034873901 / Angielski / Miękka / 410 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. 18. 2 Principle of FACE/Gel Retardation Assay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349 18. 3 Labelling of Oligosaccharides with ANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 350 18. 4 Screening of Carbohydrate Ligands for Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . 352 18. 5 Measurement of Binding Constant for the Interaction Between Protein and ANTS-Labelled Carbohydrate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 355 18. 6 Measurement of Binding Constant for the Interaction Between...
18. 2 Principle of FACE/Gel Retardation Assay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349 18. 3 Labelling of Oligosacchari...
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cena:
402,53 |
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Applied Statistics in Biomedicine and Clinical Trials Design: Selected Papers from 2013 Icsa/Isbs Joint Statistical Meetings
ISBN: 9783319126937 / Angielski / Twarda / 546 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The 6 sections cover Bayesian methods in biomedical research; Diagnostic medicine and classification; Innovative Clinical Trials Design; Modelling and Data Analysis; Personalized Medicine; and Statistical Genomics. The real world applications are in clinical trials, diagnostic medicine and genetics. The peer-reviewed contributions were solicited and selected from some 400 presentations at the annual meeting of the International Chinese Statistical...
This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The 6 ...
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cena:
603,81 |
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Methodik Der Blutuntersuchung: Mit Einem Anhang Zytodiagnostische Technik
ISBN: 9783662388235 / Niemiecki / Miękka / 492 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfangen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen fur die historische wie auch die disziplingeschichtliche Forschung zur Verfugung, die jeweils im historischen Kontext betrachtet werden mussen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben."
Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfangen des Verlags von 1842 erschienen...
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cena:
206,88 |
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Cell and Organ Printing
ISBN: 9789401785174 / Angielski / Miękka / 260 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Most successful research fields will go through different stages of development before maturation and eventually gain general acceptance. In the course of this development, it is important to periodically examine current progress, refocus goals, and explore new directions in the field. We believe the field of Cell-Printing (CP) has reached a stage when such an exercise is beneficial for all researchers involved. A number of the CP techniques have reached certain successes in the laboratory and it is time to examine their current capabilities and limitations, and establish... Most successful research fields will go through different stages of development before maturation and eventually gain general acceptance. In... |
cena:
603,81 |
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Long Acting Animal Health Drug Products: Fundamentals and Applications
ISBN: 9781489994103 / Angielski / Miękka / 392 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years.
The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and... Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such t... |
cena:
805,10 |
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Coronary Vasculature: Development, Structure-Function, and Adaptations
ISBN: 9781489973801 / Angielski / Miękka / 278 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through...
Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac my...
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cena:
442,79 |
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Managing the Prenatal Environment to Enhance Livestock Productivity
ISBN: 9789400791831 / Angielski / Miękka / 298 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prenatal life is the period of maximal development in animals, and it is well recognised that factors that alter development can have profound effects on the embryonic, fetal and postnatal animal. Scientists involved in research on livestock productivity have for decades studied postnatal consequences of fetal development on productivity. Recently, however, there has been a surge in interest in how to manage prenatal development to enhance livestock health and productivity. This has occurred largely due to the studies that show human health in later life can be influenced by events during... Prenatal life is the period of maximal development in animals, and it is well recognised that factors that alter development can have profound effe... |
cena:
603,81 |
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V(d)J Recombination
ISBN: 9781493901241 / Angielski / Miękka / 199 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant...
v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their u...
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cena:
603,81 |
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Clinical Epidemiology: Practice and Methods
ISBN: 9781493924271 / Angielski / Twarda / 533 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including...
Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and ev...
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cena:
654,14 |
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Molecular Mechanisms of Spondyloarthropathies
ISBN: 9781489990259 / Angielski / Miękka / 314 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious that over this period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. Discussion for such a book took initial form at the outstanding 4th Gent Symposium on SpA in October 2006, but was not formally commissioned by Landes Bioscience until early 2007. Molecular Mechanisms of Spondyloarthropathies aims to synthesize... It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious tha... |
cena:
805,10 |
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Introduction to Research: Understanding and Applying Multiple Strategies
ISBN: 9780323261715 / Angielski / Miękka / 416 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Bridge the gap between research and practice with Introduction to Research: Understanding and Applying Multiple Strategies, 5th Edition. This easy-to-read edition covers all the major research design strategies: qualitative, quantitative, naturalistic, experimental-type, and mixed method. And with the text's up-to-date research information and references, you will have a solid foundation from which to critique and understand research designs and their applications to healthcare and human service settings. Bridge the gap between research and practice with Introduction to Research: Understanding and Applying Multiple Strategies, 5th Edition. Thi... |
cena:
317,53 |
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Evaluation of Sleep Complaints, an Issue of Sleep Medicine C
ISBN: 9780323323451 / Angielski / Twarda / 1 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Dr. Clete Kushida has assembled an expert panel of authors focused on Sleep Complaints. Articles in this issue include: Difficulty Falling or Staying Asleep; Irregular Bedtimes and Awakenings; Snoring, Irregular Respiration, Hypoventilation, and Apneas; Periodic or Rhythmic Movements During Sleep; Nightmares and Dream-Enactment Behaviors; Poor Sleep with Age; Difficulty Falling or Staying Asleep and more!
Dr. Clete Kushida has assembled an expert panel of authors focused on Sleep Complaints. Articles in this issue include: Difficulty Falling or Staying ...
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cena:
308,51 |