Molecular Therapies of Cancer

ISBN-13: 9783319132778 / Angielski / Twarda / 2015 / 488 str.

Georg F. Weber

Opis

Molecular Therapies of Cancer sets out to comprehensively cover the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is a huge literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles with only superficial connections to each other. There is a lack of comprehensive and systematic text on the topic of molecular terapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas. Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1) Molecular Targeting of Cancer Cells 2) Emerging and Alternative Treatment Modalities 3) Molecular Targeting of Tumor-Host Interactions 4) Anti-Cancer Drug Pharmacokinetics 5) Supportive Therapies

Spis treści

INTRODUCTION

SECTION I: GENERAL PRINCIPLES

SECTION II: MOLECULAR TARGETING OF CANCER CELLS

1. DNA DAMAGING DRUGS
1.1. ALKYLATING AGENTS
1.2. ANTIBIOTICS
1.3. TOPOISOMERASE INHIBITORS
1.4. ANTI-METABOLITES

2. DRUGS THAT SUPPRESS PROLIFERATION
2.1. ANTI-MITOTIC AGENTS
2.2. DIFFERENTIATING AGENTS
2.3. INDUCERS OF APOPTOSIS

3. MOLECULAR INHIBITORS OF GROWTH SIGNALS
3.1. SMALL MOLECULE KINASE INHIBITORS
3.2. INHIBITORS OF ONCOGENE FUNCTIONS
3.3. ANTIBODIES

4. ANTI-METASTASIS THERAPY
4.1. INTEGRIN INHIBITORS
4.2. CD44 INHIBITORS
4.3. MMP INHIBITORS
4.4. CHEMOKINE RECEPTOR INHIBITORS
4.5. TGF- IHIBITORS
4.6. BONE TARGETING AGENTS
4.7. OTHERS

5. INDUCTION OF SENESCENCE
5.1. TELOMERASE INHIBITORS

6. COMBINATION CHEMOTHERAPY
6.1. TREATMENT OF HEMATOLOGIC MALIGNANCIES
6.2. TREATMENT OF SOLID TUMORS

SECTION III: EMERGING AND ALTERNATIVE TREATMENT MODALITIES

7. GENE THERAPY
7.1. GENE SILENCING
7.2. SUICIDE GENES
7.3. ONCOLYTIC VIRUSES
7.4. GENE DELIVERY
7.5. OTHER STRATEGIES

8. DRUGS WITH DIVERSE MODES OF ACTION

SECTION IV: MOLECULAR TARGETING OF TUMOR-HOST INTERACTIONS

9. HORMONE THERAPY
9.1. ANTI-ESTROGENS
9.2. ANTI-ANDROGENS
9.3. CORTICOSTEROIDS

10. IMMUNOTHERAPY
10.1. IMMUNOTOXINS
10.2. ENGINEERED ANTIBODIES
10.3. ANTIGEN BASED IMMUNOTHERAPIES
10.4. CYTOKINE BASED IMMUNOTHERAPIES
10.5. IMMUNE RESPONSE MODIFIERS
10.6. AUTOLOGOUS THERAPIES
10.7. OTHER REGIMENS

11. ANTI-ANGIOGENESIS
11.1. VEGF ANTAGONISTS
11.2. FGF-2 ANTAGONISTS
11.3. THALIDOMIDE RELATED DRUGS
11.4. INTEGRIN BLOCKERS
11.5. ENDOSTATIN AND ANGIOSTATIN
11.6. OTHERS

SECTION V: ANTI-CANCER DRUG PHARMACOKINETICS

12. DRUG DELIVERY AND DRUG TRANSPORT
12.1. TARGETING WITH DRUG CONJUGATES
12.2.

RADIO-TARGETING
12.3. NANO-PARTICLES
12.4. SOLUBILIZERS
12.5. VARIOUS

13. DRUG METABOLISM
13.1. CYP450
13.2. FLAVIN MONOOXYGENASES
13.3. GST
13.4. OTHERS

14. PRODRUG ACTIVATION
14.1. PHOTODYNAMIC THERAPY
14.2. RADIO-SENSITIZATION

15. DRUG RESISTANCE
15.1. INCREASED EFFLUX
15.2. DECREASED UPTAKE
15.3. ANTI-APOPTOSIS
15.4. MUTATIONS IN THE DRUG TARGET
15.5. ALTERED REPAIR OF DRUG INDUCED DAMAGE
15.6. OTHER MECHANISMS

SECTION VI: SUPPORTIVE THERAPY

16. PROTECTION FROM ADVERSE EFFECTS
16.1. ANTI-EMETICS
16.2. PROTECTION FROM ANEMIA
16.3. IMMUNE RECOVERY
16.4. CARDIOVASCULAR PROTECTION
16.5. ANTI-OXIDANTS
16.6. ANTI-CACHEXIA DRUGS
16.7. PROTECTION FROM HEPATOTOXICITY
16.8. PROTECTION FROM URINARY TOXICITY
16.9. PROTECTION OF THE GASTROINTESTINAL TRACT
16.10. TREATMENT OF DERMATOLOGIC REACTIONS TO CHEMOTHERAPY
16.11. ELECTROLYTE BALANCE
16.12. REPRODUCTIVE PROTECTION
16.13. OTHERS

17. PAIN MANAGEMENT
17.1. NON-STEROIDAL DRUGS
17.2. OPIOID DRUGS
17.3. OTHERS

18. PREVENTIVE TREATMENT
18.1. VACCINES
18.2. CHEMOPREVENTION

O autorze

Georg Weber, MD, PhD, is Associate Professor at the James L. Winkle College of Pharmacy at the University of Cincinnati. Dr. Weber has made contributions to metastasis research by discovering the interaction between the molecules osteopontin and CD44 and by defining the physiologic role of metastasis genes as stress response genes. While he continues to address fundamental questions, he is researching new venues for diagnosis and therapy of cancer progression. Dr. Weber's professional affiliations include the American Association for the Advancement of Science, American Medical Association, American Association for Cancer Research, and Metastasis Research Society. Dr. Weber has published several books including Molecular Mechanisms of Cancer, which was published by Springer.

Blurb

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.