Signal Transduction by Integrins
ISBN: 9780412133015 / Angielski / Twarda / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Summarizes the vast available literature on the cell surface receptors for matrix proteins, now known to function in interactions between the cell and the matrix and in the adhesion between cells. Covers general aspects of integrin structure and function, several distinct pathways involved in the transmission of the signal from the membrane to the
Summarizes the vast available literature on the cell surface receptors for matrix proteins, now known to function in interactions between the cell and...
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585,00 zł |
Carcinomas of the Head and Neck: Evaluation and Management
ISBN: 9780792306689 / Angielski / Twarda / 292 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has...
It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with...
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cena:
585,00 zł |
Disease Progression and Carcinogenesis in the Gastrointestinal Tract
ISBN: 9780792387855 / Angielski / Twarda / 260 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Development and progression of gastrointestinal disease involves inflammatory, vascular, fibrogenetic and immune reactions accompanied by deregulation of cellular growth and death often resulting in cancer of theorgans affected. This book, the proceedings of Falk Symposium 132 on Disease Progression and Carcinogenesis in the Gastrointestinal Tract', held in Freiburg, Germany, October 9-10, 2002, addresses these various cellularprocesses in five sections in order to build up a broad pathogenic concept of gastrointestinal disease, purposely going beyond organ-specific research. Each section...
Development and progression of gastrointestinal disease involves inflammatory, vascular, fibrogenetic and immune reactions accompanied by deregulation...
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cena:
585,00 zł |
New Trends in Gastric Cancer: Background and Videosurgery
ISBN: 9780792389170 / Angielski / Twarda / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Despite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate diagnosis and treatment since it has a high mortality rate. In June 1989 an International Conference was held at the University of Rome "La Sapienza" entitled "New Trends in Gastric Cancer: Background and videosurgery." During this meeting background information on the aetiopathogenesis of gastric cancer was presented together with talks and video presentations on the latest advances in the treatment of gastric carcinoma, both from the European and...
Despite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate dia...
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585,00 zł |
Endocrinology of Breast Cancer
ISBN: 9780896035911 / Angielski / Twarda / 392 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. Drawing on the multidisciplinary expertise of leading authorities, the book highlights the roles of oncogenes and tumor suppressor genes, spelling out the importance of autocrine/paracrine loops (e.g., stromal epithelial interactions) in supporting breast cancer cell proliferation and the progression to hormone independence. The book's many prominent contributors also illuminate significant recent advances in the biochemistry and physiology of...
A cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. D...
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585,00 zł |
Platinum-Based Drugs in Cancer Therapy
ISBN: 9780896035997 / Angielski / Twarda / 341 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the...
Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining...
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cena:
585,00 zł |
Farnesyltransferase Inhibitors in Cancer Therapy
ISBN: 9780896036291 / Angielski / Twarda / 280 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs); geranylgeranyltransferase inhibitors (GGTIs) are also discussed as potential anticancer drugs. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other cytotoxic agents, such as gemcitabine, cisplatin, and taxanes. Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy...
Cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs)...
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cena:
585,00 zł |
Matrix Metalloproteinase Inhibitors in Cancer Therapy
ISBN: 9780896036680 / Angielski / Twarda / 262 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety,...
Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors i...
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cena:
585,00 zł |
Hormone Therapy in Breast and Prostate Cancer
ISBN: 9780896036734 / Angielski / Twarda / 420 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In Hormone Therapy in Breast and Prostate Cancer, many of today's leading researchers and clinicians describe the principles underlying targeted hormonal treatments, assess the actions of new and established agents, and illustrate the new applications of hormonal chemoprevention for breast cancer. Topics range from preclinical and clinical antiestrogens to the inhibition of estrogen synthesis and the effects of androgen withdrawal. A wide variety of proven and new agents are discussed-antiestrogens, including aromatase inhibitors (anastrozole, letrozole, and others), SERMs (tamoxifen,...
In Hormone Therapy in Breast and Prostate Cancer, many of today's leading researchers and clinicians describe the principles underlying targeted hormo...
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cena:
585,00 zł |
Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases
ISBN: 9780896037106 / Angielski / Twarda / 578 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The...
Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inh...
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cena:
585,00 zł |
Regional Chemotherapy: Clinical Research and Practice
ISBN: 9780896037298 / Angielski / Twarda / 366 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas...
Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antine...
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cena:
585,00 zł |
Prostate Cancer Methods and Protocols
ISBN: 9780896039780 / Angielski / Twarda / 403 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prostate cancer is the second leading cancer in men in Western society. A major concern, and an area of intensive research, involves understanding why certain prostate cancers remain localized or indolent, whereas others become aggressive and metastasize. The differences between these cancer types have profound implications for patients and physicians. Indolent d- ease, which grows very slowly, generally does not cause any problems to the patient, whereas aggressive disease requires immediate treatment, the earlier the better. At present, there are no markers that discriminate between these...
Prostate cancer is the second leading cancer in men in Western society. A major concern, and an area of intensive research, involves understanding why...
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cena:
585,00 zł |
Organ Directed Toxicities of Anticancer Drugs: Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Dru
ISBN: 9780898383560 / Angielski / Twarda / 254 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif- ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in- tervention. Much of this toxicity, such as damage to the bone marrow, gastroin- testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively...
The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability t...
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cena:
585,00 zł |
Endocrine Therapies in Breast and Prostate Cancer
ISBN: 9780898383652 / Angielski / Twarda / 162 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It has been recognized for many years that cancers originating in the breast and prostate gland are frequently 'endocrine-dependent. ' Traditional thera- pies included surgical endocrine ablative procedures or pharmacologic hor- mone administration, both designed to antagonize the stimulatory effects of sex steroid hormones. In the past decade, several new treatment strategies for these tumors have emerged from basic studies in reproductive biology and mechanisms of action of steroid hormones. In some instances, these new treatments have elimin- ated or reduced the need for major surgical...
It has been recognized for many years that cancers originating in the breast and prostate gland are frequently 'endocrine-dependent. ' Traditional the...
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cena:
585,00 zł |
Biology and Therapy of Acute Leukemia: Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan -- April 12-13, 1984
ISBN: 9780898387285 / Angielski / Twarda / 259 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting top- ics of broad interest to the cancer community and examining the subject from both a basic laboratory and clinical viewpoint. In this way, the importance of both elements of cancer research are noted and the interplay between them emphasized. Further, we believe that Symposia such as this act to stimulate the basic scientist and clinician to continue their studies with the know- ledge of the impact that each has upon the other and the nec- essary cooperation required to solve...
This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting top- ics of broad interest to the ca...
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cena:
585,00 zł |
Biochemistry and Molecular Genetics of Cancer Metastasis: Proceedings of the Symposium on Biochemistry and Molecular Genetics of Cancer Metastasis Bet
ISBN: 9780898387858 / Angielski / Twarda / 334 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The success rate for treatment of primary neoplasms has improved sig nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care. In contrast, the treatment of cancer metastases, the cause of most cancer deaths, has not been very successful. Approximately 50% or more of patients with primary malignant neoplasms already have established metastases. Consequently, the most important problem in cancer treatment is the destruction or prevention of metastases. Metastases research has obvious clinical importance. Yet it has only been recently that...
The success rate for treatment of primary neoplasms has improved sig nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and ...
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cena:
585,00 zł |
Stem Cells and Their Potential for Clinical Application
ISBN: 9781402064678 / Angielski / Twarda / 274 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application which took place from August 23 25, 2006 in Kyiv and from August 26 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of...
This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical applicat...
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585,00 zł |
Stem Cells and Their Potential for Clinical Application
ISBN: 9781402064685 / Angielski / Miękka / 274 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application which took place from August 23 25, 2006 in Kyiv and from August 26 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of...
This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical applicat...
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cena:
585,00 zł |
Expression Profiling of Human Tumors: Diagnostic and Research Applications
ISBN: 9781588291226 / Angielski / Twarda / 399 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons...
A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue sa...
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cena:
585,00 zł |
Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done
ISBN: 9781588291837 / Angielski / Twarda / 386 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in...
Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible...
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cena:
585,00 zł |