Stem Cells and Their Potential for Clinical Application

ISBN-13: 9781402064678 / Angielski / Twarda / 2007 / 274 str.

Boris Fehse; Wolfram Ostertag; Carol Stocking

Opis

This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting Stem Cells and their potential for clinical application which took place from August 23 25, 2006 in Kyiv and from August 26 31, 2006 in Simeiz, Ukraine. The meeting was devoted to hot topics in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference s main topics, the book is divided into five chapters - Haematopoietic stem cells and haematopoiesis, Biology of n- haematopoietic stem cells, Stem cells and malignancy, Cell processing; expansion and genetic modification and Clinical haematopoietic stem cell transplantation ."

Spis treści

I. HAEMATOPOIETIC STEM CELLS AND HAEMATOPOIESIS. Clonal Dominance After Reconstitution of the Haematopoietic System with Bone Marrow Cells Retrovirally Transduced with Murine CD34 Variants; G.von Keudell et al.- Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Self-Renewal of Early Hematopoietic Progenitor Cells; J. Friel et al.- Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cells (HSC) Compartment; O.I. Gan et al.- Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CDF Injections; I.N. Nifontova et al.- Regulation of Hematopoiesis by Growth Factors; E.R. Stanley.- II. BIOLOGY OF NON-HAEMATOPOIETIC STEM CELLS. Stem Cell Technologies in Gerontological Research; G.M. Butenko.- Osteopetrotic Models for Identifying Genes that Control Bone Resorption; W.Wiktor-Jedrzejczak.- Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine; C. Lange et al.- Epithelial Plasticity of Hepatocytes during Liver Tumor Progression; M. Mikula et al.- Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life; M. Crisan.- III. STEM CELLS AND MALIGNANCY. Stem Cells and Leukemia; V. Bebeshko et al.- Telomere and Stem Cell Biology in Chronic Myeloid Leukemia; S. Balabanov et al.- Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules – Enemies or Friends; B. Seliger.-The RUNXI Transcription Factor: A Gatekeeper in Acute Leukemia; C. Stocking et al.- IV. CELL PROCESSING, EXPANSION AND GENETIC MODIFICATION. Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population; N.M. Bilko et al.- Animal Hybrids and Stem Cells Their Use in Biotechnology and Clinical Practice; L.P. Djakonov.- Cryopreservation of Stem Cells; V.I. Grischenko et al.- The M813 Retrovirus Belongs to a Unique Interference Group and is highly Fusogenic; V. Prassolov.- Reconstructing an Anti-TumorImmune Repertoire for Targeted AML Therapy; M. Theobald.- V. CLINICAL HAEMATOPOIETIC STEM CELL TRANSPLANTATION. Experience of Kyiv Center of Stem Cell Transplantation; V.I. Khomenko.- Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors; A.R. Zander et al.-