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The Identities of Membrane Steroid Receptors: ...and Other Proteins Mediating Nongenomic Steroid Action
ISBN: 9781402073441 / Angielski / Twarda / 208 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cheryl S. Watson University o/Texas Medical Branch Cellular steroid action has been thoroughly studied in the nuclear compartment. However, nuclear steroid receptor mechanisms have been unable to explain some of the rapid activities of steroids, partiCUlarly those which occur in a time frame of seconds to minutes reviewed in (1;2)]. Based on these and other considerations, an alternative membrane-associated receptor form was long ago proposed to exist (3). Others interpret the location of the steroid receptors mediating these rapid effects as peri membrane or cytoplasmic. New experimental...
Cheryl S. Watson University o/Texas Medical Branch Cellular steroid action has been thoroughly studied in the nuclear compartment. However, nuclear st...
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402,53 |
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Biochemistry of Hypertrophy and Heart Failure
ISBN: 9781402074349 / Angielski / Twarda / 166 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The focus of this special issue of Molecular and Cellular Biochemistry is underlying mechanisms that regulate cardiac growth. The new information provided in this special issue can be utilized to design new treatment modalities that will reduce the incidence of cardiac failure which will improve quality of life in patients with chronic heart disease.
The focus of this special issue of Molecular and Cellular Biochemistry is underlying mechanisms that regulate cardiac growth. The new...
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402,53 |
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Application of Solution Protein Chemistry to Biotechnology
ISBN: 9781420073416 / Angielski / Twarda / 456 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Reflecting the versatility of the author s science and the depth of his experience, Application of Solution Protein Chemistry to Biotechnology explores key contributions that protein scientists can make in the development of products that are both important and commercially viable, and provides them with tools and information required for successful participation. One of the of the world s most respected protein researchers, Roger Lundblad does not succumb to the notion that new is always better. The application of protein science to the practice of... Reflecting the versatility of the author s science and the depth of his experience, Application of Solution Protein Chemistry to Biotechnol... |
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1028,53 |
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Gender Dysphoria : Interdisciplinary Approaches in Clinical Management
ISBN: 9781560244738 / Angielski / Miękka / 172 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Provides comprehensive treatment approaches for a wide spectrum of presentations of gender dysphoria, the condition of being ill at ease with one's gender. This text stresses the need for evaluating and treating the disorder in the context of the client's overall physical and mental health.
Provides comprehensive treatment approaches for a wide spectrum of presentations of gender dysphoria, the condition of being ill at ease with one's ge...
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181,17 |
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Oxidants, Antioxidants and Free Radicals
ISBN: 9781560326441 / Angielski / Twarda / 388 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume collates articles investigating antioxidant, oxidant and free radical research. It examines the role of such research in health and disease, particulary with respect to developing greater understanding about the many interactions between oxidants and antioxidants, and how such substances may act as natural protectants and /or natural toxicants.
This volume collates articles investigating antioxidant, oxidant and free radical research. It examines the role of such research in health and diseas...
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1714,21 |
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Chemistry of Peptide Synthesis
ISBN: 9781574444544 / Angielski / Twarda / 290 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques yield the most desirable reactions. The book encompasses all factors affecting synthesis and peptide formation. Developed from the author's extensive teaching career, the book emphasizes learning rather than memorization. Topics include stereomutation, the applicability of coupling reactions, solid-phase synthesis, protection of functional groups, aminolysis, acidolysis, and the use of scavengers. It uses clear language and schematics to present concepts methodically and progressively,...
Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques yield the most desirable reactions. The book...
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1150,97 |
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Fluid, Electrolyte, and Acid-Base Regulation
ISBN: 9781583481974 / Angielski / Miękka / 256 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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134,68 |
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Molecular Biology of Drug Addiction
ISBN: 9781588290601 / Angielski / Twarda / 346 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They...
A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological ba...
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603,81 |
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Antibody Engineering: Methods and Protocols
ISBN: 9781588290922 / Angielski / Twarda / 562 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Kohler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious high target specificity, adaptability to a wide range of disease states, and the potential ability to...
The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hy...
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603,81 |
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Atomic Force Microscopy: Biomedical Methods and Applications
ISBN: 9781588290946 / Angielski / Twarda / 394 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The natural, biological, medical, and related sciences would not be what they are today without the microscope. After the introduction of the optical microscope, a second breakthrough in morphostructural surface analysis occurred in the 1940s with the development of the scanning electron microscope (SEM), which, instead of light (i. e., photons) and glass lenses, uses electrons and electromagnetic lenses (magnetic coils). Optical and scanning (or transmission) electron microscopes are called far-field microscopes because of the long distance between the sample and the point at which the image...
The natural, biological, medical, and related sciences would not be what they are today without the microscope. After the introduction of the optical ...
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603,81 |
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P53 Protocols
ISBN: 9781588291066 / Angielski / Twarda / 280 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of this protein. Several unique properties of p53 posed a challenge to understa- ing its normal function in the initial phase of its research. The low levels of p53 in normal cells, its stabilization under situations of genotoxic stress, induction of growth arrest, and apoptosis with stabilization of the protein, obstructed the visibility of its normal, unmutated function. The property of p53 that can sense a promoter and transactivate or inhibit...
Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of ...
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402,53 |
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Chiral Separations: Methods and Protocols
ISBN: 9781588291509 / Angielski / Twarda / 432 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism....
Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to...
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402,53 |
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Igf and Nutrition in Health and Disease
ISBN: 9781588291905 / Angielski / Twarda / 359 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This text stands alone as it provides the first authoritative review on the role of nutrition as it pertains to the IGF system. By taking a multidisciplinary approach, the importance of nutrition and the IGF system in the pathology and treatment of conditions such as diabetes, renal failure, inflammatory bowel diseases, critical illness, wasting disease, neurological disorders, cardiovascular disease and cancer are explored. Even for health professionals not directly involved in IGF research, the text contributes greatly to the understanding of the mechanisms of growth arrest and metabolic...
This text stands alone as it provides the first authoritative review on the role of nutrition as it pertains to the IGF system. By taking a multidisci...
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603,81 |
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Nitric Oxide Protocols
ISBN: 9781588292377 / Angielski / Twarda / 248 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It has been more than five years since the appearance of the first edition of Nitric Oxide Protocols. According to Medline, more than 32,500 publications dealing with nitric oxide have appeared in the primary literature in the int- vening time from 1999 to April 2004. These numbers attest to the continuing vitality of a field dealing with a deceptively simple, although extremely int- esting and promiscuous molecule, nitric oxide. Despite its apparent chemical simplicity, nitric oxide continues to amaze, with an extremely wide spectrum of functions and effects. In particular, the last few...
It has been more than five years since the appearance of the first edition of Nitric Oxide Protocols. According to Medline, more than 32,500 publicati...
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402,53 |
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Ubiquitin-Proteasome Protocols
ISBN: 9781588292520 / Angielski / Twarda / 381 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery,...
A collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from...
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402,53 |
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Protein Nanotechnology: Protocols, Instrumentation, and Applications
ISBN: 9781588293107 / Angielski / Twarda / 466 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Protein Nanotechnology: Protocols, Instrumentation, and Applications is an authoritative reference for a broad audience involved in nanotechnology research and in the teaching, learning, and practice of nanotechnology for genomics, proteomics, bioengineering, and medicine. This volume presents the most recent scientific and technological advances of nanobiotechnology, as well as the practical methods and applications of it. Each chapter provides introductory material with an overview of the topic of interest; a description of methods, protocols, instrumentation, and applications; and a...
Protein Nanotechnology: Protocols, Instrumentation, and Applications is an authoritative reference for a broad audience involved in nanotechnology res...
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603,81 |
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Phosphodiesterase Methods and Protocols
ISBN: 9781588293145 / Angielski / Twarda / 336 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Adenosine 3,5 -cyclic monophosphate (cAMP) and guanosine 3,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first and second messengers. In concert with intracellular calcium and IP3, they play a major role in the control of intracellular signaling, which orchestrates normal and pathophysiological responses. Downstream from the cyclic nucleotide synthesis by adenylyl and guanylyl cyclases, the multigenic family of cyclic nucleotide phosphodiesterases (PDEs), by specifically hydrolyzing cyclic nucleotides, controls cAMP and cGMP levels to maintain a basal...
Adenosine 3,5 -cyclic monophosphate (cAMP) and guanosine 3,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first an...
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402,53 |
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Stroke Genomics: Methods and Reviews
ISBN: 9781588293336 / Angielski / Twarda / 351 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has yet to be realized. More than most diseases, stroke has been keenly studied from a genomic perspective. Studies are numerous and incorporate data on stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery. The problem is no longer a lack of information but one of interpretation and prioritization of what we do know. The aims of Stroke Genomics: Methods and...
With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has ye...
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402,53 |
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Therapeutic Proteins: Methods and Protocols
ISBN: 9781588293909 / Angielski / Twarda / 482 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based "drugs" that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact-...
With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets ...
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603,81 |
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Pesticide Protocols
ISBN: 9781588294104 / Angielski / Twarda / 504 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive collection of robust methods for the detection of pesticide compounds or their metabolites useful in food, environmental, and biological monitoring, and in studies of exposure via food, water, air, and the skin or lungs. The readily reproducible methods range from gas and liquid chromatography coupled to mass spectrometry detection and other classic detectors, to capillary electrophoresis and immunochemical or radioimmunoassay methods. The authors have focused on extraction and cleanup procedures, in order to develop and optimize more fullyautomated and miniaturized methods,...
A comprehensive collection of robust methods for the detection of pesticide compounds or their metabolites useful in food, environmental, and biologic...
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603,81 |
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