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Reactive Oxygen Metabolites: Chemistry and Medical Consequences
ISBN: 9780849308918 / Angielski / Twarda / 608 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In recent years, the field of radical chemistry has undergone explosive growth. Although its roots lie in organic chemistry, the implications of its findings are having enormous impact in a broad range of disciplines, and we now have evidence for radical involvement in over 100 diseases. As important as this is, however, the subject of radicals and reactive oxygen metabolites (ROMs) is complex and barely touched upon in the curriculum of medical schools.
Reactive Oxygen Metabolites brings the subject within the grasp of even those with little preparation in chemistry. From the basic... In recent years, the field of radical chemistry has undergone explosive growth. Although its roots lie in organic chemistry, the implications of its f...
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1313,76 |
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Calcium Signalling in Cancer
ISBN: 9780849309427 / Angielski / Twarda / 384 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feature of cell adhesion and motility; the integrity of the calcium binding proteins themselves is a basic requirement of normal biological function. In fact, the deregulation of calcium signaling is now regarded as the primary event in the...
Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of phys...
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1313,76 |
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Flavonoids : Chemistry, Biochemistry and Applications
ISBN: 9780849320217 / Angielski / Twarda / 1237 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. < P> Advances in the flavonoid field have been nothing short of spectacular over the last 20 years. While the medical field has noticed flavonoids for their potential antioxidant, anticancer and cardioprotectant characteristics, growers and processors in plant sciences have utilized flavonoid biosynthesis and the genetic manipulation of the flavonoid pathway in plants to improve the nutritional and ornamental value of crops. Flavonoids: Chemistry, Biochemistry and Applications covers each class of flavonoid and presents the historic advances made in flavonoid research since the 1994...
< P> Advances in the flavonoid field have been nothing short of spectacular over the last 20 years. While the medical field has noticed flavonoids for...
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cena:
1933,46 |
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Amyloid Precursor Protein: A Practical Approach
ISBN: 9780849322457 / Angielski / Twarda / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated characterization techniques available.
Exploring a variety of biological techniques to clarify the structure and function of this transmembrane protein, this text presents each method with detailed, step-by-step protocols to achieve reproducible results and provide a framework for studying other membrane proteins. In the search for an effective treatment for Alzheimer's disease, APP is a unique model protein that illustrates the wide array of basic and sophistic...
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cena:
1165,03 |
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G Protein-Coupled Receptors: Structure, Function, and Ligand Screening
ISBN: 9780849327711 / Angielski / Twarda / 336 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.
This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of part...
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1313,76 |
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Lipid Second Messengers
ISBN: 9780849333835 / Angielski / Miękka / 160 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A detailed methodology for analysis of various lipid signalling pathways. Authoritative contributors explain the factors that regulate lipid second messenger production by agonist-activated enzymes and examine their products. Topics discussed include procedures used to measure lipid-derived mediators such as lysophospholipids, arachidonic acid, eicosanoids, anandamide and ceramides, and the enzymes responsible for generating these messengers, such as phospholipases, prostaglandin endoperoxide synthases and sphingomyelinase.
A detailed methodology for analysis of various lipid signalling pathways. Authoritative contributors explain the factors that regulate lipid second me...
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cena:
619,70 |
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Element Analysis of Biological Samples: Principles and Practice
ISBN: 9780849354243 / Angielski / Twarda / 272 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Despite the development of innovative new analytical techniques for biological trace element research, today's trace element investigators face formidable obstacles to obtaining reliable data. This complete reference identifies and assesses the challenges the analyst encounters at each stage of an analysis, and discusses the effects of various techniques on the sample.
Three internationally recognized scientists and authors consider the effects of the numerous collection, storage, and sample preparatory techniques used in sample analysis. Proper analytical quality control, including such... Despite the development of innovative new analytical techniques for biological trace element research, today's trace element investigators face formid...
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1313,76 |
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Analysis of Carbohydrates by GLC and MS
ISBN: 9780849368516 / Angielski / Twarda / 304 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive guide to analysis of carbohy-drates by gas-liquid chromatography and mass spectrometry. Explaining the facets of carbohydrate analysis and their relation to each other, it also contains reference in-formation useful to practitioners in the field. It highlights improvements in car-bohydrate analyses methodology.
A comprehensive guide to analysis of carbohy-drates by gas-liquid chromatography and mass spectrometry. Explaining the facets of carbohydrate analysis...
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cena:
2875,39 |
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Proteins of Iron Metabolism
ISBN: 9780849386763 / Angielski / Twarda / 608 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The comprehensive coverage of the advances in understanding the mechan isms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation o f iron metabolism. Proteins of Iron Metabolism fills the need for a cl early written, comprehensive review of the latest research, putting ev ery thing you need in one easy-to-use resource.
The comprehensive coverage of the advances in understanding the mechan isms controlling cellular iron metabolism, especially at the molecular level, f...
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cena:
991,52 |
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Cyclic Nucleotide Phosphodiesterases in Health and Disease
ISBN: 9780849396687 / Angielski / Twarda / 728 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.
Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents.... Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progre...
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1363,33 |
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Glycoanalysis Protocols
ISBN: 9780896033559 / Angielski / Twarda / 262 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Protein glycosylation is now acknowledged as a major posttranslational modification with significant effects on protein folding, conformation distri- bution, stability, and activity. The added oligosaccharide chains are large and diverse and have specific recognition motifs important in many aspects of cell interactions and regulation. As such, there is a growing need to communicate the analytical methods of the specialist carbohydrate chemist, biochemist, and physicochemist to protein experts and the pharmaceutical industry. Other areas that come under the influence of the glycosciences are...
Protein glycosylation is now acknowledged as a major posttranslational modification with significant effects on protein folding, conformation distri- ...
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cena:
538,41 |
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G Proteins, Receptors, and Disease
ISBN: 9780896034303 / Angielski / Twarda / 324 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. "Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia...
"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased produ...
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cena:
1076,87 |
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Endothelin: Molecular Biology, Physiology, and Pathology
ISBN: 9780896034365 / Angielski / Twarda / 274 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles...
A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinica...
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cena:
832,11 |
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Phospholipid Signaling Protocols
ISBN: 9780896034914 / Angielski / Twarda / 380 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cell membranes are not, as once believed, inert structures designed to contain the cell contents, but are in fact dynamic structures that are as me- bolically active as the cytosol and other cellular compartments they surround. Thus membranes not only contain mixtures of lipid and phospholipids, but also many proteins both embedded deeply within the membrane structure itself and also more loosely attached on the membrane surfaces. Though many such proteins have long been known to act as transport proteins, ion channels, hormone receptors, G proteins, cytoskeletal anchorage points, and so on,...
Cell membranes are not, as once believed, inert structures designed to contain the cell contents, but are in fact dynamic structures that are as me- b...
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cena:
538,41 |
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Aging Methods and Protocols
ISBN: 9780896035829 / Angielski / Twarda / 385 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Aging is an almost universal process within biological systems, one which leads to a decline in functional capacity, disease onset, and eventually death. There has been much interest in recent years to elucidate the molecular mec- nisms that underlie the aging process. Many theories have been proposed since the last century that aim to explain the causes of aging. There is no one theory that completely satisfies the phenotype of aging, but genetics and environm- tal factors play an important role in the etiology of age-related pathologies and the aging process. However, there is still much to...
Aging is an almost universal process within biological systems, one which leads to a decline in functional capacity, disease onset, and eventually dea...
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cena:
406,31 |
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PCR Protocols
ISBN: 9780896036277 / Angielski / Miękka / 556 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book, which has been used in more than 10,000 laboratories worldwide. As PCR technology has advanced significantly since the first edition, and has expanded its use in the clinical laboratory of physician/researchers, the scope of this book is greatly expanded to enable researchers at all levels to easily reproduce and adapt PCR experiments to their own specific requirements. The meethods selected represent worked examples from many fields that can...
Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book...
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cena:
406,31 |
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Calpain Methods and Protocols
ISBN: 9780896036321 / Angielski / Twarda / 342 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The purpose of Calpain Methods and Protocols is quite straightf- ward: it is to present the actual experimental methods used in many different laboratories for the study of calpain. It will provide the vital experimental detail, and the discussion of possible pitfalls, for which the standard journals no longer provide space. This will make it as easy as possible for investi- tors interested in calpain to adopt established methods without repeating old mistakes, and to adapt and apply these methods in novel approaches to the many outstanding calpain questions. These questions range from purely...
The purpose of Calpain Methods and Protocols is quite straightf- ward: it is to present the actual experimental methods used in many different laborat...
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cena:
538,41 |
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DNA Repair Protocols: Prokaryotic Systems
ISBN: 9780896036437 / Angielski / Twarda / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. When setting out to decide on the content of DNA Repair Protocols: Prokaryotic Systems, I was conscious of the need to portray the vast array of pathways and enzymatic activities that are part of the discipline of DNA repair. In addition to the classical DNA repair activities, I wanted to convey the significant interest that has been generated in recent years in the use of the proteins and repair systems as research tools, much like the use of restriction enzymes over the last few decades. Therefore, in addition to chapters deta- ing protocols for investigating specific repair activities, I...
When setting out to decide on the content of DNA Repair Protocols: Prokaryotic Systems, I was conscious of the need to portray the vast array of pathw...
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cena:
406,31 |
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Amino Acid Analysis Protocols
ISBN: 9780896036567 / Angielski / Twarda / 265 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Amino acid analysis is a technique that has become commonplace in biotechnology, biomedical, and food analysis laboratories. This book describes a variety of amino acid analysis techniques and how each technique can be used to answer specific biological questions. The first two chapters in Amino Acid Analysis Protocols introduce the concepts, basic theory, and practice of amino acid analysis. The following chapters give detailed instructions on various methods and their applications. As highlighted, there are many different approaches to amino acid ana- sis, but in all cases the results...
Amino acid analysis is a technique that has become commonplace in biotechnology, biomedical, and food analysis laboratories. This book describes a var...
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cena:
406,31 |
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Protein Kinase Protocols
ISBN: 9780896037007 / Angielski / Twarda / 365 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understand biological funtions and molecular interactions not only in normal development and cellular physiology, but also in diseases. However, utili- tion of these resources can come only from the development and application of a fully integrated set of molecular, biochemical, biophysical, and genetic skill bases. As key components of many cell signalling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and...
The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understan...
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cena:
406,31 |
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