La présente étude comprend la formulation et l'évaluation d'un comprimé matriciel à libération prolongée d'un médicament antiviral. Pour cette étude, l'Acyclovir a été choisi comme médicament modèle. Pour cette étude, nous avons utilisé un polymère naturel. Pour améliorer la performance de la matrice et les caractéristiques de libération, un additif hydrophile soluble dans l'eau comme le lactose et le stéarate de magnésium a été ajouté. Cette étude traite des investigations menées dans le but de développer des formulations orales à libération prolongée à travers...

In the present research work an attempt has been made to optimize, formulate and evaluate pH sensitive multiparticulate system of salbutamol sulphate to achieve chronotherapeutic drug delivery for nocturnal asthma. The whole research work performed stepwise such as preformulation studies, development of core microparticle and development of coated microparticle, In the preformulation studies salbutamol sulphate was characterized physiochemical properties such as melting point, solubility, UV and FTIR. UV spectrophotometric method was established for quantitative estimation of drugs in the...

The present study includes the Formulation and Evaluation of Mucoadhesive Buccal Patch of Timolol Maleate for this study work timolol maleate selected as model drug and using either ionic polymers (SCMC) or non-ionic polymers (carbopol, HPMC).The fabricated patches were prepared by solvent casting method. The mean thicknesses of the buccal patch formulations were 0.34 - 0.43 mm.Moisture uptake of transdermal patches were found to be 2.94-4.13.which prevents the patches from microbial growth and bulkiness. As amount of PVP increased in every polymer blend, tensile strength and elongation at...

In present work attempts have been made to formulate and evaluate colontargeted capsules of Ibuprofen by using polymer Sodium alginate, Xanthangum, Chitosen and Eudragit used as coating. Ibuprofen show anti-inflammatory activity. Ibuprofen meets all the ideal characteristics to formulate in the form of colon drug delivery system. Mucoadhesive polymers whose mucoadhesive properties had been reported were used along with alginate for the preparation of capsules. The mucoadhesive polymers used in the formulations were xanthan gum, eudragit, and chitosan. The capsules were prepared by orifice...

The present study includes the formulation and evaluation of sustained release matrix tablet of Antiviral drug. For this study Acyclovir selected as model drug. For this study using natural polymer. To improve matrix performance and release characteristics, a water soluble hydrophilic additive like lactose Mg stearate was added. This study deals with the investigations carried out with the objective of developing oral sustained release formulations through matrix tablets for the widely used Antiviral drug Acyclovir using natural gum as Taro gum and evaluation of their sustained release...

The present study includes the design and development of Novel sustained release solid dosage form of ant tubercular drug by natural polysaccharide. First the isolation of polysaccharide studies done as development process where physical, chemical and mechanical properties of a new polysaccharide were characterized by different parameters. The Isoniazid tablets were prepared by wet granulation method using natural polysaccharide at different ratio. Prepared granules were evaluated for pre compressive parameters such as Bulk density, Tapped density, Powder Compressibility, Powder flow property...

Die vorliegende Studie umfasst die Formulierung und Bewertung einer Matrix-Tablette mit verzögerter Freisetzung eines antiviralen Medikaments. Für diese Studie wurde Acyclovir als Modellmedikament ausgewählt. Für diese Studie wurde ein natürliches Polymer verwendet. Um die Leistung der Matrix und die Freisetzungseigenschaften zu verbessern, wurde ein wasserlösliches hydrophiles Additiv wie Laktose und Mg-Stearat hinzugefügt. Diese Studie befasst sich mit den Untersuchungen, die mit dem Ziel durchgeführt wurden, orale Formulierungen mit verzögerter Freisetzung durch Matrixtabletten...