Development of Mucoadhesive Buccal Patch of Timolol Maleate

ISBN-13: 9786204211381 / Angielski / Miękka / 132 str.

Dharmendra Solanki; Madhuri Patidar

Opis

The present study includes the Formulation and Evaluation of Mucoadhesive Buccal Patch of Timolol Maleate for this study work timolol maleate selected as model drug and using either ionic polymers (SCMC) or non-ionic polymers (carbopol, HPMC).The fabricated patches were prepared by solvent casting method. The mean thicknesses of the buccal patch formulations were 0.34 - 0.43 mm.Moisture uptake of transdermal patches were found to be 2.94-4.13.which prevents the patches from microbial growth and bulkiness. As amount of PVP increased in every polymer blend, tensile strength and elongation at break were increased. Addition of PVP predominantly decreased the swelling characteristics of the buccal patches, except for SCMC. The drug content of the prepared bioadhesive buccal patches were found in the range of 91.4 - 98.54 %.Bioadhesive strength of buccal patches in following order SCMC >Carbopol>HPMC. The release of Timolol maleate from HPMC patches was slower than SCMC and CP 934.

O autorze

Solanki, DharmendraProf (Dr.) Dharmendra Solanki .Currently working as Professor and Principal at LNCP Indore. He earned PhD degree in pharmacy from Department of pharmaceutical science Berhampur University, Orrisa. and worked on study of traditional medicine and isolation of different polysaccharides, their evaluation and specification tests.