A series of novel 2-(substituted benzylidene)-7-(4-bromophenyl)-5-(furan-2-yl)-2H-thiazolo 3,2-a]pyrimidin-3(7H)-ones were synthesized by using established methods and were characterized by IR, 1H NMR and Mass spectroscopy in order to confirm their formation. These compounds were synthesized to evaluate their antitubercular, antibacterial and antifungal potency. Docking studies revealed the importance of functional groups and its different biological action. They were found to be potent against Mycobacterium tuberculosis H37Ra strain, also potent against Gram +ve, Gram -ve and fungal strains

A series of Ethyl-3-methyl-5-(substituted-phenyl)-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazoline-2-carboxylate derivatives have been synthesize from cyclohexanone and substituted benzaldehyde with the aim of developing potential antimicrobials and antitubercular agents. It was characterized by FT-IR, 1H NMR and Mass spectroscopy. All the newly synthesized compounds were screened for their antimicrobial and antifungal activities on Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus cereus (Gram-positive bacteria), Escherichia coli, Pseudomonas aeruginosa,...

Quinazoline is the main six-membered heterocyclic ring system reported for their biological activities, compounds with multiple pharmacophores, which bring together knowledge of a target with understanding of the molecule types that might interact with the target family. Robust, versatile and scalable chemistry must be employed to accomplish the task. This characteristic feature of quinazoline would make a good template for a lead generation library. The current review article focuses on biological actions done for various targets along with the brief description of the targets.

These novel one and thione derivatives were synthesized by using established methods and were characterized by IR, 1H NMR and Mass spectroscopy in order to confirm their formation. These compounds were synthesized to screen for their antibacterial, antifungal and antitubercular activities. The compounds were found to be potent against Gram +ve, Gram -ve bacterial, fungal and H37Ra strains. In the view of result the most active compounds are carrying thiourea and its dominating urea derivatives.

Review is a major component to carry out the research work. The review on quinazoline, substituted amine, semicarbazide derivatives furnishes its established biological activities. Thus quinazoline scaffold is not only synthetically important but also possesses a wide range of promising biological activities. Future investigations of this scaffold could give some more encouraging results. The selected review on quinazoline and fused quinazoline derivatives and its anticancer, antimicrobial activities are initiative to researchers those who involved in the medicinal chemistry research

A variety of novel pyrimidine, thiosemicarbazide and semicarbazide derivatives have been reviewed. Based on brief review of compounds will be subject to in vitro assessment for their antitumor and antimicrobial activities, and compounds are believed to be the most active members in this study. The tested compounds exhibit excellent anticancer and antimicrobial activities against both clinical cancer isolates and microbial pathogenic strains.

Development in biological evaluation of heterocyclic molecules has undergone manifold changes and the advancement in molecular biology has eased the design of new molecules based on their mechanism of action. Proposed work is based upon the development of newer analogues of benzothiazoles followed by their biological evaluation. Benzothiazoles have been reported with good biological activities ranging from antiparasitic, anti-inflammatory, antitumour, p56lck inhibition, immunosuppressive antitubercular activity etc. The derivatives of benzothiazoles have been developed very recently,...

A variety of imidazole, and fused imidazole derivatives have been reviewed. Continuous efforts on combination of lead optimization and molecular modeling studies in synthesis and the structure activity relationship studies and biological activities of novel modi ed imidazole, and fused imidazole derivatives, allowed to identi cation of novel imidazole derivatives as potent anti TB, antimicrobial and antidepressant agents."

Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine have been reviewed. Based on review the pyrimidine derivatives will obtained by the various condensation methods. The structures of these compounds will evident by elemental analysis such as, IR, 1H NMR and mass spectral analysis. These biologically important pyrimidine and fused pyrimidine compounds will investigated for their antiinflammatory, antibacterial, antifungal and antiTB activities

A detailed review on HIV and its drugs was prepared. This broad spectrum of biochemical targets has been facilitated by the synthetic versatility of heterocyclic compounds, which has allowed the generation of a large number of structurally diverse derivatives. The objective of this review to systematically evaluate the pharmacological properties of various substituted heterocyclic compounds and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies. This is the first review to comprehensively discuss the HIV and its drugs.