This review has been aimed at the treatment of rheumatoid arthritis and their significance. Rheumatoid arthritis is the most important systemic disease. The current review information has been found to reveal both remarkable active medicine and a variety of valuable practical applications. An interest in the exploration of this medicine has undoubtedly been growing due to their proven utility as attractive lead structures for the design of novel agents with a mechanism of action that sometimes differs from that of clinically authorized current antirheumatic drugs. Therefore, in the present...

Tuberculosis remains primary cause of comparatively high mortality worldwide. The statistics highlighted that three million people worldwide die annually from complication of TB and there are estimated 8 million of new cases each year, and today more people die from tuberculosis than ever before. In recent history, however, poor compliance with the prolonged and complicated chemotherapeutic regimens currently used to treat the disease, in conjunction with the advent of the AIDS epidemic and the increased mobility of human populations, has led to the emergence of numerous multidrug resistant...

From detailed literature survey, various techniques are now a days available for determination of Naproxen and Sumatriptan in bulk as well as in dosage forms. Also methods are made available for estimation of these drugs in plasma. Among the different methods available HPLC and UV spectroscopy has gained considerable importance and are widely used. Proper analysis and estimation of these drugs is very crucial and the dose related side effects could be combatted.

Naproxen is chemically, (2S)-2-(6-methoxy naphthalen-2-yl) propanoic acid. It is a propionic acid derivative related to the aryl acetic acid group of non-steroidal anti-inflammatory drugs. It is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of moderate to severe pain, fever, inflammation and stiffness. Esomeprazole is chemically, (S)-5-methoxy-2- (4-methoxy-3,5-dimethyl-2-pyridinyl) methyl]-sulfinyl]-1H-benzimidazole. It is a gastric proton-pump inhibitor (PPI) used in treatment of gastric-acid related diseases. Simple, selective and accurate analytical...

A variety of five membered N-heterocyclic derivatives have been reviewed. Based on brief review, the compounds have been subjected for assessment of their pharmacological activities, and it's believed that these compounds found to be the most active for their further studies. The objective of this review is to systematically evaluate the pharmacological properties of various substituted five membered N-heterocyclic compounds and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies.

In the present study, we have reported the effect of thiazole based derivatives as potent anticancer agents. The review report helps to elucidate further the structure activity relationship (SAR) studies on the anticancer activity of thiazole moiety. Results suggest that the position, number of substituent and its bulkiness at thiazole ring play a key role in inhibiting the proliferation of cancer cells. In general, the thiazole analogs displayed better anticancer activity. Therefore, the selected review on thiazole moiety and its cancer treatment are initiative to researchers those who...

A varicose vein is a venous disorder and the word varicose comes from the Latin word "varix" (meaning "twisted"). Up to 25 % of women and 18 % of men will suffer from varicose veins. Nearly 50 % of untreated patients eventually experiences chronic venous insufficiency. Varicose veins are more common in women than men. Superficial veins of the leg are under high pressure; hence this disorder is mostly seen in the leg. There is no cure for varicose veins which means that you have to treat and monitor them on a regular basis. Hence, the better option for varicose vein is prevention than cure.

The literature survey comprehensively documented the pyrazole and its derivatives as significantly important class of heterocyclic compounds possessing a wide spectrum of biological activities against anticancer, antimicrobial, antiinflammatory, antitubercular, analgesic, etc. Pyrazole are readily available and series of compounds has been synthesized by countless modification in various positions on the pyrazole nucleus that has displayed improved biological activity. The compounds are further characterised and evaluated for desire pharmacological activity with high potency and low toxicity.

Cancer is one of the leading causes of death in people. People from any age group may get cancer. Cancer is not usually detected in early stages, so awareness should be created among all the age groups about the early cancer signs and symptoms as identifying and diagnosing them would save a life. The aim of the present work is, researcher should know all the basic information about the various treatments available for treating cancer as well as importance of thiazole nucleus.