Thiazole - An Active Scaffold Against Bacterial Strains

ISBN-13: 9783659324390 / Angielski / Miękka / 2013 / 200 str.

Panneer Selvam Theivendren;James Caiado Richa;Arumugam Sivakumar

Opis

A series of Ethyl-3-methyl-5-(substituted-phenyl)-6,7,8,9-tetrahydro-5H-thiazolo[2,3-b]quinazoline-2-carboxylate derivatives have been synthesize from cyclohexanone and substituted benzaldehyde with the aim of developing potential antimicrobials and antitubercular agents. It was characterized by FT-IR, 1H NMR and Mass spectroscopy. All the newly synthesized compounds were screened for their antimicrobial and antifungal activities on Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus cereus (Gram-positive bacteria), Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia (Gram-negative bacteria), Aspergillus fumigates, Candida albicans (Fungi). All the synthesized compounds were also evaluated for their antitubercular activity against Mycobacterium tuberculosis strain H37Ra.

O autorze

Theivendren Panneer Selvam was born in 1981 (Bodi, Tamilnadu, India). He received his PG Pharmacy degree 2007 from Dr. M.G.R. Medical University, India and his Ph.D in 2013 from Acharya Nagarjuna University, India. His research has focused on the Design, Synthesis, Spectral,InSilico, InVitro & InVivo Screening of Novel Heterocyclic Derivatives.