The first six volumes of the Handbook reviewed basic neuropharmacology, drawing on expertise in biochemistry, pharmacology and electrophysiology. The next three volumes focus attention on the functional importance of these basic neuropharmacological mechanisms for normal behavior. In order to study this interface in the intact functioning organism, appropriate methods for describing and quantifying behavior must be developed. The past twenty years have witnessed a revolution in the study of behavior which has taken us away from the often fruitless theoretical arguments to descriptive...

The first six volumes of the Handbook reviewed basic neuropharmacology, drawing on expertise in biochemistry, pharmacology and electrophysiology. The next three volumes focus attention on the functional importance of these basic neuropharmacological mechanisms for normal behavior. In order to study this interface in the intact functioning organism, appropriate methods for describing and quantifying behavior must be developed. The past twenty years have witnessed a revolution in the study of behavior which has taken us away from the often fruitless theoretical arguments to descriptive...

It is now eight years since the first Handbook volumes on Basic Neuro- pharmacology were published, and there have been many important advances. As in many other areas in science, progress in this field has depended to a considerable extent on the availability of new experimental methods, and Volume 15 reviews some major recent developments, including new autoradiographic techniques that allow direct visualization of drug and transmitter receptors in the nervous system, and the pin- pointing of the precise locations of the changes in brain metabolism elicited by various drug treatments....

Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas...

Perhaps more than any other group of psychotropic drugs, the neuroleptics are a focus for integrating clinical application, neurotransmitter disposition, and pathophysiologic mechanisms of mental illness. Neuroleptic is a term referring to drugs of several chemical classes-phenothiazines, thioxan thenes, and butyrophenones-which have in common a selective ability to alleviate schizophrenic symptoms. Delay and Deniker derived the word neuroleptic from the Greek meaning "to grasp the neuron. " They coined the name because they noted that therapeutic responses to chlorpromazine tended to...

The first six volumes of the Handbook reviewed basic neuropharmacology, drawing on expertise in biochemistry, pharmacology and electrophysiology. The next three volumes focus attention on the functional importance of these basic neuropharmacological mechanisms for normal behavior. In order to study this interface in the intact functioning organism, appropriate methods for describing and quantifying behavior must be developed. The past twenty years have witnessed a revolution in the study of behavior which has taken us away from the often fruitless theoretical arguments to descriptive...

Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas...

Volumes 7 and 8 of the Handbook were published in 1977. In Volume 7 methods for studying unconditioned and conditioned behavior were reviewed. Attention was given to both ethological methods and operant conditioning techniques as applied to some selected aspects of behavior. Genetic, developmental, and environmental factors influencing behavior were also discussed. In Volume 8, neurotransmitter systems, and in par ticular brain circuits, were discussed in relation to behavior and to the effects of psychoactive drugs on behavior. The coverage was not exhaus tive because of space limitations....