This text covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents, with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral binding inhibitors (anionic compounds and CD4 mimetics) and various plant-derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory...

Recognition of the importance of complex oligosaccharides in a variety of biological processes has stimulated a massive effort to synthesize them. This work presents a review of oligosaccharide synthesis leading from classical methods through to the state-of-the-art technology.

This volume presents a systematic and unified treatment of Leray-Schauder continuation theorems in nonlinear analysis. In particular, fixed point theory is established for many classes of maps, such as contractive, non-expansive, accretive, and compact maps, to name but a few. This book also presents coincidence and multiplicity results. Many applications of current interest in the theory of nonlinear differential equations are presented to complement the theory. The text is essentially self-contained, so it may also be used as an introduction to topological methods in nonlinear analysis....

Ion -Selective Electrodes for Biological Systems provides a user-friendly and practical guide to the manufacture and use of ion-selective electrodes for a wide variety of experimental systems used in biology. The book is aimed at researchers with little practical experience in the field and will direct them through the steps involved in making electrodes, interpretation of the data, requirements of the recording apparatus, potential pitfalls involved in their use, and the range of situations in which they can be used.
This is the first book that deals comprehensively with such practical...

An edited collection of papers given at the third Design and Emotion Conference 2002, these contributions outline developments, findings and techniques in industrial applications and in research, bringing the reader up to date with the current thinking in this field.

This text covers the proceedings of a conference where information derived from behavioural studies, using teleost fish as models, was presented, discussed and reviewed.

Photodynamic therapy (PDT) is a ground breaking medical technique which uses lasers to activate light-sensitive chemicals to treat cancer and other diseases without resorting to surgery. For the first time, Chemical Aspects of Photodynamic Therapy introduces in an accessible way the physics, chemistry and biology behind the technique. This highly authoritative account of the account of the rapidly developing field of PDT explores its chemical basis, while presenting information in its historical context. Haematoporphyrin derivative is considered in detail, together with the new 'second...