Modern Methods in Carbohydrate Synthesis

ISBN-13: 9783718659210 / Angielski / Miękka / 1996 / 576 str.

Raymond Bonnett; Khan H. Khan; Shaheer H. Khan

Opis

Recognition of the importance of complex oligosaccharides in a variety of biological processes has stimulated a massive effort to synthesize them. This work presents a review of oligosaccharide synthesis leading from classical methods through to the state-of-the-art technology.

Spis treści

1. Twenty Five Years of Carbohydrate Chemistry; An Overview of Oligosaccharide Synthesis 2. The Anomeric O-Alkylation and the Trichloroacetimidate Method - Versatile Strategies for Glycoside Bond Formation 3. Synthesis of Glycosyl Halides for Oligosaccharide Synthesis Using Dihalogenomethyl Methyl Ethers 4. Glycosylation Properties and Reactivity of Thioglycosides, Sulfoxides, and other S-glycosides: Current Scope and Future Prospects 5. Phenyl Selenoglycosides as Versatile Glycosylating Agents in Oligosaccharide Synthesis and the Chemical Synthesis of Disaccharides Containing Sulfur and Selenium 6. Synthesis and Use of S-Xanthates, Carbohydrate Enol Ethers and and Related Derivatives in the Field of Glycosylation 7. n-Pentenyl Glycosides in Oligosaccharide Synthesis 8. Coupling of Glycals: A New Strategy for the Rapid Assembly of Oligosaccharides 9. Advances in Polymer-Supported Solution Synthesis of Oligosaccharides 10. Protecting Groups in Oligosaccharide Synthesis 11. Synthesis of ss-D-Mannose Containing Oligosaccharides 12. Synthesis of Sialoglycoconjugates 13. Synthetic Studies on Cell-Surface Glycans: An Approach to O-linked Sialoglycoprotein 14. Synthesis of C-Glycosides; Stable Mimics of O-Glycosidic Linkages 15. Recent Developments in Glycopeptide Synthesis 16. Design and Synthesis of Glycoconjugates 17. Synthesis of Biologically Active Sulfated and Phosphorylated Oligosaccharides 18. Synthetic Glycosyltransferase Acceptors and Inhibitors; Useful Tools in Glycobiology 19. Practical Synthesis of Oligosaccharides Based on Glycosyltransferases and Glycosylphophites 20. Use of Glycosyltransferases in the Synthesis of Unnatural Oligosaccharide Analogues 21. Synthesis with Glycosidases

O autorze

Shaheer H. Khan (Applied Biosystems, Forster City, California, USA) (Author)