Anti-AIDS Drug Development

ISBN-13: 9783718656981 / Angielski / Twarda / 1995 / 304 str.

Raymond Bonnett

Opis

This text covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents, with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral binding inhibitors (anionic compounds and CD4 mimetics) and various plant-derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory proteins, the development of anti-HIV-1 assays and resistance to anti-HIV-1 agents.

Spis treści

1. From Anti-HIV Agents to Anti-AIDS Chemotherapy: A Critical Appraisal 2. Nucleosides and Derivatives 3. Iminosugar a-Glucosidase Inhibitors 4. Inhibition of HIV Protease: A Strategy for the Treatment of AIDS 5. Regulatory Proteins of Hum an Immunodeficiency 6. CD4 Mimetics and Analogs 7. Antisense Oligonucleotide Approach for Therapy of AIDS 8. Resistance to Anti-HIV Agents for Anti-AIDS Drug Development 9. Anti-HIV Drug Test Systems: Significance and Limitations 10. Plant-derived Anti-HIV Agents 11. HIV-1-specific Reverse Transcriptase Inhibitors 12. Small and Large Polyanionic Derivatives

O autorze

Mohan, Prem; Masanori, Baba