This book describes the role modern pharmaceutical analysis plays in the development of new drugs. Detailed information is provided as to how the quality of drug products is assured from the point of discovery until the patient uses the drug. Coverage includes state-of-the-art topics such as analytics for combinatorial chemistry and high-throughput screening, formulation development, stability studies, international regulatory aspects and documentation, and future technologies that are likely to impact the field. Emphasis is placed on current, easy-to-follow methods that readers can apply in...
This book describes the role modern pharmaceutical analysis plays in the development of new drugs. Detailed information is provided as to how the qual...
Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The only current book on the market, the Handbook of Isoelectric Focusing and Proteomics is the ideal 'one-stop' source for germane information in this discipline. This highly practical book also contains chapters on alternative methods that may pave the way in the search for efficient techniques for fractionating and purifying proteins. Complete with the history of IEF focusing to authors' insights and practical tips, this book is a must...
Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The ...
High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms,...
High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring cha...
This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to emphasize the influence of the different bioseparation processes on protein inactivation. Bioseparation of Proteins covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. The book focuses on the avoidance of protein...
This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins ...
Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections: 1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis 2. Spectroscopic Methods 3. Chromatographic Methods 4. Electrophoretic and Electrochemical Methods 5. Combination Methods, Unique Detectors, and Problem Solving Each section has a...
Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in...
For the analyses of DNA and RNA, high pressure/performance liquid chromatography (HPLC) is proving extremely useful as trace and ultratrace analyses can provide potentially helpful data for diagnostic studies. This text deals with both analyses, executed at or below ppm level, and with on-column injection at low microgram or nanogram level. A variety of applications, studies and methods are used as focal points for discussion, along with theoretical and equipment considerations.
For the analyses of DNA and RNA, high pressure/performance liquid chromatography (HPLC) is proving extremely useful as trace and ultratrace analyses c...
The current state-of-the-art relative to the optimization of selection and detection in high performance liquid chromatography is thoroughly handled in this large volume. Among the 13 chapters is a contribution from Lloyd Snyder on the physiochemical basis of retention. The book will be of interest to analytical chemists, biochemists and chemical engineers.
The current state-of-the-art relative to the optimization of selection and detection in high performance liquid chromatography is thoroughly handled i...
The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of...
The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug p...
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These...
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceut...
Monitoring Water Quality is a practical assessment of one of the most pressing growth and sustainability issues in the developed and developing worlds: water quality. Over the last 10 years, improved laboratory techniques have led to the discovery of microbial and viral contaminants, pharmaceuticals, and endocrine disruptors in our fresh water supplies that were not monitored previously.
This book offers in-depth coverage of water quality issues (natural and human-related), monitoring of contaminants, and remediation of water contamination. In particular, readers will learn...
Monitoring Water Quality is a practical assessment of one of the most pressing growth and sustainability issues in the developed and develop...
