With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of mapping procedures as they were developed in classical genetics. An accompanying volume - From Molecular Genetics to Genomics - covers the history of molecular genetics and genomics. The book shows that the technology of genetic mapping is by no means a recent acquisition of molecular genetics or even genetic engineering. It demonstrates that the development of mapping technologies has accompanied the rise of modern genetics from its very beginnings. In Section One,...
With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of mapping procedures as they were dev...
With the rise of genomics, the life sciences have entered a new era. Maps of genomes have become the icons for a comprehensive knowledge of the organism on a previously unattained level of complexity. This book provides an in-depth history of molecular genetics and genomics. The first section of the book shows how the cartography of classical genetics was linked to the molecular analysis of gene structure through the introduction of new model organisms, such as bacteria, and through the invention of new experimental tools, such as gene transfer. The second section addresses the development of...
With the rise of genomics, the life sciences have entered a new era. Maps of genomes have become the icons for a comprehensive knowledge of the organi...
In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology. In a post-Kuhnian move away from the hegemony of theory, he develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things. A central concern of the book is the basic question of how novelty is generated in the empirical sciences. In addressing this question, the author brings French poststructuralist thinking--notably Jacques Derrida's concepts of...
In this powerful work of conceptual and analytical originality, the author argues for the primacy of the material arrangements of the laboratory in th...
Advances in molecular biological research in the past forty years have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? This book is unique in that it is the first interdisciplinary volume, written by philosophers, historians, and working scientists, solely devoted to the quest for the gene. It will be of interest to professionals and students...
Advances in molecular biological research in the past forty years have made the story of the gene vastly complicated: the more we learn about genes, t...
Research records composed of notes and protocols have long played a role in the efforts to understand the origins of what have come to be seen as the established milestones in the development of modern science. The use of research records to probe the nature of scientific investigation itself however is a recent development in the history of science. With Eduard Dijksterhuis, we could address them as a veritable "epistemologiCal laboratory." The purpose of a workshop entitled "Reworking the Bench: Laboratory Notebooks in the History of Science," held at the Max Planck Institute for the...
Research records composed of notes and protocols have long played a role in the efforts to understand the origins of what have come to be seen as the ...
Mit Geschichte und Epistemologie knpft Hans-Jrg Rheinberger an seine Studien zu Experimentalsystemen und epistemischen Dingen an, die er als treibende Momente der Entwicklung der modernen Naturwissenschaften identifiziert. Im Mittelpunkt stehen dabei die Biowissenschaften des 20. Jahrhunderts. Im ersten Abschnitt des Buches geht es um die grundlegenden Bedingungen einer Historisierung des wissenschaftlichen Wissens. Der zweite Abschnitt thematisiert anhand von Fallstudien die Rolle von Modellorganismen in den Wissenschaften vom Leben. Im dritten Teil wird das Verhltnis von Apparatur und...
Mit Geschichte und Epistemologie knpft Hans-Jrg Rheinberger an seine Studien zu Experimentalsystemen und epistemischen Dingen an, die er als treibende...
Wenn das 19. Jahrhundert in der Philosophie der Wissenschaften den Aufstieg des Positivismus erlebte, so begann das 20. Jahrhundert mit einer Krise des positivistischen Denkens, ohne dass zunächst eine Lösung oder gar Alternative in Sicht gewesen wäre. Erst allmählich entwickelte sich im Laufe des 20. Jahrhunderts ein komplexes, sozialhistorisch und denkhistorisch motiviertes Nachdenken über Wissenschaft, das in seinem Kern darin bestand, die Wissenschaftsphilosophie zu historisieren. Es entwickelten sich Formen einer historischen Epistemologie. Diese Bewegung muss in den breiteren...
Wenn das 19. Jahrhundert in der Philosophie der Wissenschaften den Aufstieg des Positivismus erlebte, so begann das 20. Jahrhundert mit einer Krise de...
Seine Position als zentrales organisierendes Thema der Biologie des 20. Jahrhunderts verdankt das Gen weniger endgültigen wissenschaftlichen Befunden als vielmehr der Tatsache, daß der ihm entsprechende Forschungsgegenstand, sein epistemisches Objekt also, sich Zug um Zug instrumentell vermittelter, experimenteller Handhabung erschloß.§Mit der Komplettierung der Sequenzen ganzer Genome, insbesondere des Humangenoms, ist die Genetik als Wissenschaft ein Kind des 20. Jahrhunderts erneut an den Rand eines grundlegenden Denkwandels getreten. Vielfach werden Stimmen laut, die den Genbegriff zu...
Seine Position als zentrales organisierendes Thema der Biologie des 20. Jahrhunderts verdankt das Gen weniger endgültigen wissenschaftlichen Befunden...
It was only around 1800 that heredity began to enter debates among physicians, breeders, and naturalists. Soon thereafter it evolved into one of the most fundamental concepts of biology. Here Staffan Muller-Wille and Hans-Jorg Rheinberger offer a succinct cultural history of the scientific concept of heredity. They outline the dramatic changes the idea has undergone since the early modern period and describe the political and technological developments that brought about these changes. Muller-Wille and Rheinberger begin with an account of premodern theories of generation, showing that...
It was only around 1800 that heredity began to enter debates among physicians, breeders, and naturalists. Soon thereafter it evolved into one of th...
With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of mapping procedures as they were developed in classical genetics. An accompanying volume - From Molecular Genetics to Genomics - covers the history of molecular genetics and genomics. The book shows that the technology of genetic mapping is by no means a recent acquisition of molecular genetics or even genetic engineering. It demonstrates that the development of mapping technologies has accompanied the rise of modern genetics from its very beginnings. In Section One,...
With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of mapping procedures as they were dev...
