From Molecular Genetics to Genomics : The Mapping Cultures of Twentieth-Century Genetics

ISBN-13: 9780415328500 / Angielski / Twarda / 2004 / 240 str.

Jean-Paul Gaudilliere; Hans-Jorg Rheinberger

Opis

With the rise of genomics, the life sciences have entered a new era. Maps of genomes have become the icons for a comprehensive knowledge of the organism on a previously unattained level of complexity. This book provides an in-depth history of molecular genetics and genomics. The first section of the book shows how the cartography of classical genetics was linked to the molecular analysis of gene structure through the introduction of new model organisms, such as bacteria, and through the invention of new experimental tools, such as gene transfer. The second section addresses the development of human genome sequencing in all its technical, epistemic, social, and economic complexity. With its detailed analyses of the scientific practices and its illustration of the diversity of mapping, this book is a significant contribution to the history of genetics. A companion volume from the same editors - Classical Genetic Research and Its Legacy: The mapping cultures of twentieth century genetics - covers the history of mapping procedures as they were developed in classical genetics.

Spis treści

Section 1. Molecularizing Maps1. Angela Creager. Mapping Genes in Microorganisms2. Frederic L. Holmes. Seymour Benzer and the Convergence of Molecular Biology with Classical Genetics3. Marcel Weber. Walking on the Chromosome: Drosophila and the Molecularization of Development4. Scott Gilbert. Gene Expression Maps: The Cartography of Transcription5. Soraya de Chadarevian. Mapping the Worm's Genome: Tools, Networks, PatronageSection 2. The Moral and the Political Economy of Human Genome Sequencing6. Stephen Hilgartner. Making Maps and Making Social Order: Governing American Genome Centers, 1988-937. Alain Kaufmann. Mapping the Human Genome at Généthon Laboratory: The French Muscular Dystrophy Association and the Politics of the Gene8. Adam Bostanci. Sequencing Human Genomes9. Gísli Pálsson. Decoding Relations and Disease: The Icelandic Biogenetic Project

O autorze

Jean-Paul Gaudillière is a senior researcher at the National Institute of Health (INSERM), Paris. His work has addressed many aspects of the history of molecular biology and of the biomedical sciences during the twentieth century. His contemporary research focuses on the history of biological drugs. He is the co-editor of Heredity and Infection: A History of Disease Transmission (2002). Hans-Jörg Rheinberger is Director at the Max Planck Institute for the History of Science in Berlin. He has published numerous papers and books in molecular biology and the history of science, including a co-edited collection, The Concept of the Gene in Development and Evolution (2000).