This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is...

Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.

• Mitochondrial Ubiquinone and Reductases
• Anticancer Quinones and Quinone Oxido-Reductases
• Quininone Reductases: Chemoprevention, Nutrition
• Quinones and Age-Related Diseases

This volume on conjugation enzymes and transporters serves to bring together current methods and concepts in an interesting, important and rapidly developing field of cell and systems biology. Phase II Conjugation Enzymes and Transport Systems focuses on the so-called Phase II enzymes of drug metabolism (xenobiotics), which has important ramifications for endogenous metabolism and nutrition. Also included are aspects on Phase III, transport systems. This volume of Methods in Enzymology presents current knowledge and methodology on glucuronidation, sulfation, acetylation, and...

This text focuses on the natural healing properties of antioxidants, revealing the full range of healing benefits of lipoic acid, the most versatile and powerful antioxidant and nature's secret weapon in treating heart disease. The astonishing strength of the antioxidant network - the combination of vitamin E, vitamin C, lipoic acid, Co Q10, and glutathione - is also shown. When taken together in the proper amounts, the combination battles disease and ageing far more aggressively than supplements taken individually. After an accessible explanation of the science behind antioxidants, Packer...

This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms.
Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity
With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology

focuses on important biological...

Promoting scientific support for the plethora of health benefits related to nutrition and medicine, this book delivers an overview of the research findings in disease prevention, therapy, and enhanced body function in the revolutionary field of nutraceutical technology - with highlights from Nutraceutical Conference held in Ludwigshafen, Germany.

This volume illustrates the impact of environmental oxidants on the tissues of the eyes, lungs and skin, as well as on the immune system - highlighting common illnesses, injuries and pathologies induced by pro-oxidant environmental xenobiotics such as inflammation, immune response, signal transduction, regulation of gene expression, and carcinogenesis. It provides clinical presentations and discusses the effects of environmental oxidants on target organs.

Covers antioxidants in beverages and herbal products, nitric oxide and selenium. This book highlights research on food-derived antioxidants and biomarkers; vitamins E and C; coenzyme Q; carotenoids, flavoroids and other polyphenols; antioxidants in beverages and herbal products; and, the thiol antioxidants glutathione and lipoic acid.

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area.
Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants
Featuring the research of over 55 experts in the area, Understanding the Process of Aging

covers the functions of nitric oxide and peroxynitrite in mitochondria

integrates several views on the role of mitochondria in the development of...

Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF).