Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and...
Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecul...
In their analysis of experiments and in their planning of syntheses, organic chemistsconsciouslyorunconsciouslytendtousetheprincipleofleastmotion, thechemicalequivalentofOccam'srazor. Inrearrangementreactionsthispr- ciple is violated and may make rearrangements problematic reactions. At the sametime, thereisalwaysfascinationintheunexpectedandsorearrangement reactionsarealsoanattractive?eldofstudy. Consequently, ourunderstanding of rearrangement reactions is now quite advanced and allows strategic uses in organic synthesis. Here, a helpful tool that may easily be overlooked is thein?uence...
In their analysis of experiments and in their planning of syntheses, organic chemistsconsciouslyorunconsciouslytendtousetheprincipleofleastmotion, the...
Keeping up with the advances in modern heterocyclic chemistry is essential for many of our colleagues in academia and industry. It is the aim of this series on "Stereoselective Heterocyclic Synthesis" to assist the chemical community in this respect by presenting a selection of exciting recent developments. As it was for the first two volumes (1997), the stereoselective synthesis of - or with the aid of - heterocycles is the common motif for all the chapters in this third volume. I am very glad that again leading researchers in this area have contrib- ed highly stimulating accounts with...
Keeping up with the advances in modern heterocyclic chemistry is essential for many of our colleagues in academia and industry. It is the aim of this ...
This book presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The book is still valid and useful after 5 or 10 years. More information as well as the electronic version of the whole content is available at: springerlink.com. The book will interest scientists and practitioners in the mentioned fields and in industry.
This book presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on...
Time-dependent density functional response theory for electronic chiroptical properties of chiral molecules; by Jochen Autschbach, Lucia Nitsch Velasquez, and Mark Rudolph
*
Chiroptical Properties of Charge-Transfer Compounds; by Yoshihisa Inoue, Tadashi Mori
*
G-C content independent long-range charge transfer through DNA; by Tetsuro Majima
*
Induced chirality in porphiryn aggregates: the role of weak and strong interactions; by Roberto Purrello
*
Vibrational circular dichroism spectroscopy of chiral molecules in solution; by Yunjie Xu...
Time-dependent density functional response theory for electronic chiroptical properties of chiral molecules; by Jochen Autschbach, Lucia Nitsch Vel...
Recent Advances in the Synthesis of Morphine and Related Alkaloids; by N. Chida * Opioids in Preclinical and Clinical Traials; by K. Kawai and S. Sakami * Twin and Triplet Drugs in Opioid; by H. Fujii * Synthesis of Neoclerodane Diterpenes (Salvinorin Derivatives) and Their Pharmacological Effects; by T. E. Prisinzano * Synthesis of Novel Basic Opioid Skeletons Derived from Naltrexone; by H. Nagase * Nonpeptidic d Opioid Agonists: What Have We Learned?; by S. N. Calderson * Synthesis of 14-Alkoxy- and 14-Aminomorphinan Derivatives and Their Pharmacological Actions; by H. Schmidhammer and M....
Recent Advances in the Synthesis of Morphine and Related Alkaloids; by N. Chida * Opioids in Preclinical and Clinical Traials; by K. Kawai and S. Saka...
Includes: Synthesis in the Key of Catellani: Norbornene-Mediated ortho C-H Functionalization; Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation; and Palladium and Copper Catalysis in Regioselective, Intermolecular Coupling of C-H and C-Hal Bonds.
Includes: Synthesis in the Key of Catellani: Norbornene-Mediated ortho C-H Functionalization; Mechanistic Considerations in the Development and Use of...
Key Building Blocks via Enzyme-Mediated Synthesis, by Thomas Fischer and Jorg Pietruszka * Engineered Biosynthesis of Plant Polyketides: Structure-Based and Precursor-Directed Approach, by Ikuro Abe * Enzymatic and Chemo-Enzymatic Approaches Towards Natural and Non-Natural Alkaloids: Indoles, Isoquinolines, and Others, by Joachim Stockigt, Zhong Chen, and Martin Ruppert * Chemoenzymatic and Bioenzymatic Synthesis of Carbohydrate Containing Natural Products, by Bohdan Ostash, Xiaohui Yan, Victor Fedorenko, and Andreas Bechthold * Total (Bio)Synthesis: Strategies of...
Key Building Blocks via Enzyme-Mediated Synthesis, by Thomas Fischer and Jorg Pietruszka * Engineered Biosynthesis of Plant Polyketides: Structu...
