Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view. Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and...
Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes a...
The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is...
The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the p...
From being to becoming important, myo-inositol and its derivatives including phosphoinositides and phosphoinositols involved in diversi?ed functions in wide varieties of cells overcoming its insigni?cant role had to wait more than a century. Myo-inositol, infact, is the oldest known inositol and it was isolated from muscle as early as 1850 and phytin (Inositol hexakis phosphate) from plants by Pfeffer in 1872. Since then, interest in inositols and their derivatives varied as the methodology of isolation and puri?cation of the stereoisomers of inositol and their derivatives advanced....
From being to becoming important, myo-inositol and its derivatives including phosphoinositides and phosphoinositols involved in diversi?ed functions i...
The Coronin Family of Proteins Christoph S. Clemen, * Vasily Rybakin and Ludwig Eichinger he coronins, first described in Dictyostelium discoideum in 1991, have meanwhile been detected in all eukaryotes except plants. They belong to the superfamily of WD40-repeat Tproteins and represent a large family of proteins, which are often involved in cytoskeletal functions. Phylogenetic studies clearly distinguish 12 subfamilies of which six exclusively occur in vertebrates. In the present book we have made a sincere attempt to provide a comprehensive overview on all aspects of coronin proteins...
The Coronin Family of Proteins Christoph S. Clemen, * Vasily Rybakin and Ludwig Eichinger he coronins, first described in Dictyostelium discoideum in ...
The present volume is the first attempt to bring together, in a comprehensive and comparative manner, the vast knowledge accumulated on the mycoplasma cell membranes. The state-of-the-art coverage includes physical studies of lipid organization and dynamics in mycoplasma membranes, the role of cholesterol in mycoplasma membranes, spiralins, and eight other subjects.
The present volume is the first attempt to bring together, in a comprehensive and comparative manner, the vast knowledge accumulated on the mycoplasma...
In step with the surge of interest in the endoplasmic reticulum, the current volume takes an integrated look at this functionally diverse organelle. Coverage includes protein translocation and export, lipid metabolism, antigen presentation, and many other subjects, gleaned from such diverse fields as cell biology, enzymology and membrane biochemistry, immunology, and signal transduction.
In step with the surge of interest in the endoplasmic reticulum, the current volume takes an integrated look at this functionally diverse organelle. C...
This latest volume summarizes the current state of knowledge of membrane assembly. It covers subjects germane to most membranes as well as to membranes of different organelles for prokaryote, plant, and animal cells.
This latest volume summarizes the current state of knowledge of membrane assembly. It covers subjects germane to most membranes as well as to membrane...
In biological terms, a parasite can be defined as an organism that grows, feeds and is sheltered on, or in, a different organism while contributing nothing to the survival of the host. 1 This relationship is particularly intimate for parasitic protozoa (and single-celled fungi such as the Microsporidia), many of which not only penetrate tissue barriers, but gain entry into host cells. The entry mechanisms are as diverse as the organisms employing them and are often critical components of their pathogenic profile. All of the parasitic organisms highlighted in this new book represent...
In biological terms, a parasite can be defined as an organism that grows, feeds and is sheltered on, or in, a different organism while contributing...
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and...
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulator...
This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellu...
