The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is...
The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the p...
Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view. Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and...
Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes a...
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens-not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue...
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the glob...
Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volume will cover the recent milestone developments in this field by leading experts, uniting theory and experiment, and selecting contributions to illustrate important aspects of the mechanisms of electron and radical transfer in proteins. Features:
A demonstration of the key principles controlling biological redox reactions;
Experimental studies of simple' soluble systems in various enzyme familiies to illustrate concepts...
Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volum...
Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broad range of topics, including key steps in the cholesterol biosynthetic pathway, and the role of cholesterol in cancer, atherosclerosis, and diseases of the nervous system. The book's comprehensive coverage also includes the pathological consequences and potential therapies for various disease states, and the development of new anti-atherogenic drugs.
Experts investigate the biochemical and biomedical aspects of cholesterol, addressing its metabolism in normal and disease states. They discuss a broa...
Surveys a range of representative approaches for understanding the organization, interaction, and dynamics of both lipid and protein components within the biological membrane. Some of them have a long history in the study of soluble proteins and have only recently been applied to the study of membra
Surveys a range of representative approaches for understanding the organization, interaction, and dynamics of both lipid and protein components within...
Volume 18 of the Subcellular Biochemistry series, which specializes in various aspects of the biochemistry of the intracellular parasites, was initially proposed by Jose Luis Avila and strongly supported by myself, as Series Editor of Sub cellular Biochemistry. Considerable assistance was received from Professor Frank Wunderlich (University of Dusseldorf) and more particularly from Dr. Michael Miles (London School of Hygiene and Tropical Medicine) during the compilation of the list of possible chapters. Our initial aim was to present a comprehensive survey of this broad field of study....
Volume 18 of the Subcellular Biochemistry series, which specializes in various aspects of the biochemistry of the intracellular parasites, was initial...
Endotoxins explores the mechanism behind whole-body inflammation and sepsis by synthesizing the leading research in the field. The biosynthesis, genetic constitution, and structure ofendotoxins are presented, in addition to their interaction with host cells.
Endotoxins explores the mechanism behind whole-body inflammation and sepsis by synthesizing the leading research in the field. The biosynthesis, genet...
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+ 1 a a 4 + 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and ...
Strategies of Bacterial Interaction with Eukaryotic Cells *Tobias A. Oelschlaeger and Jorg Hacker 1. BENEFICIAL BACTERIAL-HOST INTERACTIONS Already during birth and soon thereafter mammals are colonized by bacte ria belonging to the resident microbial flora. Cutaneous and mucosal sur faces and the gastrointestinal tract are the areas which become colonized. These indigenous or autochthonous bacteria have a variety of beneficial effects on their hosts. They play a protective role by bacterial antagonism in fighting infections (Hoszowski and Truszczynski, 1997; Hentges, 1979). Pro duction of...
Strategies of Bacterial Interaction with Eukaryotic Cells *Tobias A. Oelschlaeger and Jorg Hacker 1. BENEFICIAL BACTERIAL-HOST INTERACTIONS Already du...
