This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases.

The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or...

This book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis and organogenesis. It also reviews pathogen-induced syncytia and the role of syncytial cells in cancer development.

The book covers the following topics:

• germline syncytia, evolution, function and structure;
• syncytia in embryogenesis and development;
• the role of somatic cell fusion in fungi, specialized somatic tissues, host defense and adaptation;
• syncytia induced by viruses and...

This book provides a comprehensive overview of the molecular basis of developmental and stem cell regulation. It revisits some of the classical models of developmental biology and puts them in context with the findings of modern stem cell research and developmental biology. 

Biomedical research is embarking on a new era due to new tools, which are exemplified by stem cell technologies, single-cell transcriptome analysis, and live imaging at a single-cell resolution. Publications based on cutting-edge technologies do often not provide the readers with deep biological backgrounds....