The cerebral neo cortex, unique to mammals, is regarded as the prerequisite for higher cognitive function and is the structure most closely associated with the idea of the "mind" . Expansion of mental capa city between mammals is most typically associated with an evolutionary increase in neocortical volume that culminates in the intricately folded configuration of sulci and gyri so charac- teristic of the primate cerebral cortex. Yet, the basic unit structure and funda- mental connectivity of cortex appears to have been preserved from the smooth cortex of the mouse or rat to the highly...
The cerebral neo cortex, unique to mammals, is regarded as the prerequisite for higher cognitive function and is the structure most closely associated...
Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity and complexity. This view has been changed, however, by the discovery of differential subcellular RNA distribution patterns. Over the past decade it has become clear that selective mRNA sorting and translation contributes to an accumulation of cognate proteins at discrete cellular sites. In this book, various systems are discussed (e.g. Xenopus oocytes, mammalian brain, invertebrate nervous system) in terms of RNA trafficking, RNA-targeting sequences (cis-elements)...
Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity and complexity. This v...
This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.
This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. To...
Darlison's excellent work reviews aspects of GABA-A receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABA-C receptors and G-protein coupled receptors including neuropeptides. Glycine receptors and potassium channels are covered too. The consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are also discussed.
Darlison's excellent work reviews aspects of GABA-A receptor function, as well as the properties of a variety of other important inhibitory protein...
The fermentation of sugar by cell-free yeast extracts was demonstrated more than a century ago by E. Buchner (Nobel Prize 1907). Buchner's observations put an end to previous animistic theories regarding cellular life. It became clear that metabolism and all cellular functions should be accessible to explication in chemical terms. Equally important for an understanding of living systems was the concept, explained in physical terms, that all living things could be cons- ered as energy converters E. Schrodinger (Nobel Prize 1933)] which generate complexity at the expense of an increase in...
The fermentation of sugar by cell-free yeast extracts was demonstrated more than a century ago by E. Buchner (Nobel Prize 1907). Buchner's observation...
The chapters of this book review the latest research in the field. Most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is placed not only on their discovery but also on their functional significance.
The chapters of this book review the latest research in the field. Most of them are written by the original discoverers of the respective novel neurop...
Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic...
Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infer...
Muscle development of vertebrates has been a paradigm of cell differentiation for many years. Three types of muscle are found in the vertebrate body: skele tal, heart and smooth muscle, and there has been a gradient of concern about these different muscle types in the sequence they are mentioned here. Skeletal muscle has received much attention because it can be induced to differentiate in vitro and because of the clinical relevance of myopathies. The discovery of the muscle-specific members of the bHLH and MADS families of transcription factors must be regarded as a breakthrough not only in...
Muscle development of vertebrates has been a paradigm of cell differentiation for many years. Three types of muscle are found in the vertebrate body: ...
Despite major efforts by the scientific community, our understanding of the pathogenesis or the mechanisms of injury of multiple sclerosis is still limited. This book investigates the molecular basis of multiple sclerosis and summarizes recent advances.
Despite major efforts by the scientific community, our understanding of the pathogenesis or the mechanisms of injury of multiple sclerosis is still li...
Plant cells contain various types of plastid, the best known among which is the chloroplast. Apart from their predominant interest for the work on photo synthesis, however, chloroplasts have attracted considerable attention for other reasons. This pertains to extranuclear inheritance of cell organelles and, particularly important for this series, to the participation of chloroplasts as discrete and partly autonomous cell constituents in the developmental biochemistry of plants. This volume is composed of articles by investigators who are actively involved in work on various aspects of...
Plant cells contain various types of plastid, the best known among which is the chloroplast. Apart from their predominant interest for the work on pho...
