Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

ISBN-13: 9783031065750 / Angielski / Miękka / 2023

Opis

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases.The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems.The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus.  Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Spis treści

1. Almouzni Pettinotti Genevieve genevieve.almouzni@curie.fr 

Research center at the Institut Curie, Head of the Chromatin Dynamics team , Member of the Science Academy in France, Co-Chair of the LifeTime Initiative, website https://lifetime-fetflagship.eu 

Histone H3 variants – chaperones and their contribution to nuclear architecture

2. Borsuk Ewa, Kubiak J.Z, Kloc M

Dep. Embryology, University of Warsaw, Warsaw Poland

borsuk@biol.uw.edu.pl 

Histones modifications in mouse pronuclei and their consequences for embryo development 

3. Bridger Joanna Joanna.Bridger@brunel.ac.uk 

Brunel University London, Biosciences, Dept of Life Sciences

College of Health , Medical and Life Sciences (CHMLS), Institute Environment, Health and Societies, Brunel University London, Uxbridge, UB8 3PH, United Kingdom

T +44(0)1895 274000

Joanna M. Bridger; Annabelle Lewis, Cristina Pina, Sabrina Tosi, Paola Vagnarelli.

Alterations to genome organisation in cellular differentiation and disease.

4. Burgess Sean M.  smburgess@ucdavis.edu 

University of California Davis, One Shields Avenue, Davis, CA 95616

             Phone: 530 754 5177

Email: smburgess@ucdavis.edu 

Meiotic chromosome dynamics in zebrafish 

5. Capelson, Maya capelson@pennmedicine.upenn.edu 

Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

The role of nuclear envelope/nuclear pore components in gene regulation.

6. Coverley Dawn dawn.coverley@york.ac.uk; and Grace Dobbs

Department of Biology, University of York, York YO10 5DD, United Kingdom

Nuclear condensation and chromosome rearrangement in quiescence in relation to compromised functionality in cancer cells

7. Faustino Randolph S.  randolph.faustino@sanfordhealth.org 

Genetics and Genomics Group, Sanford Research, 2301 East 60th St. N, Sioux Falls, SD 57104, USA, Phone #: (605) 312-6443

Roles for nuclear pores in differentiation

8. Frietze Seth E seth.frietze@med.uvm.edu , and Karen Glass, Joeseph Boyd, Kate Quinn, Cong Gao

              University of Vermont, Burlington, VT, USA

Evaluation of chromatin regulatory factors across the molecular subtypes of breast cancer

9. Gerton, Jennifer JEG@stowers.org , and Alexandria Cockrell

      Stowers Institute for Medical Research, Kansas City, MO, USA

Nucleolar organizer regions

10. Guichet Antoine Antoine.GUICHET@ijm.fr 

Morphogenesis and Polarity Unit, Institut Jacques Monod, 75005 Paris, France; and Quantitative Image Analysis Unit, Institut Pasteur, 75724 Paris, France

Microtubules and Nuclear positioning in Drosophila

11. Hausmann Michael hausmann@kip.uni-heidelberg.de 

Kirchhoff-Institute for Physics, Heidelberg University, Im Neuenheimer Feld 227, 69120 Heidelberg, Germany

Michael Hausmann, Martin Falk, Götz Pilarczyk, Georg Hildenbrand et al.

Network and Islands of Genome Nanoarchitecture and their Potential Relevance for Radiation Biology

12. Hieda Miki (Matsumura) mikihieda@gmail.com 

Osaka University, Graduate School of Medicine and Health Science, Suita City, Osaka, Japan, and Ehime Prefectural University of Health Science, s, Tobe-cho, Ehime, Japan

The interplay between nucleoskeleton and cytoskeleton.

13. Huang Yuanjian. yhuang14@mdanderson.org; Zhang Shengzhe.SZhang23@mdanderson.org; Park Jae-Il. jaeil@mdanderson.org

Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer    Center, 6565 MD Anderson Blvd.Unit 1052, Houston, TX 77030

Nuclear Actin Dynamics in Orchestrating Gene Expression 

14. Kimura Akatsuki akkimura@nig.ac.jp ; and Dr. Takahiro Sakaue (Aoyama Gakuin University, Japan, sakaue@phys.aoyama.ac.jp 

Cell Architecture Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, JAPAN, Phone: +81-55-981-5854

How nuclear size affects physical properties and functions of chromatin

15. Knoch Tobias Aurelius ta.knoch@taknoch.org 

Biophysical Genomics Group, Department of Cell Biology and Genetics, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

How Genomes Emerge, Function, and Evolve: Living Systems Creation - Genotype-Phenotype-Multilism - Genome/Systems Ecology, or

3D organization in respect to polymer simulations of entire cell nuclei, or

What we can learn from various experiments finalizing the 3D structure, whether we can understand this and what follows, or

New evaluation of interaction mapping data 

16. Latonen Leena leena.latonen@uef.fi 

K. Albin Johansson Cancer Research Fellow, Institute of Biomedicine, University of Eastern Finland, PO BOX 1627, 70211 Kuopio, Finland, tel: +358-50-3465553

leena.latonen@uef.fi 

Nuclear organization, especially focusing on responses to stress and drug treatments

17. Lele Tanmay P tanmay.lele@tamu.edu 

Texas A&M University Department of Biomedical Engineering, College Station, Texas

Nuclear structure in cancer 

18. Maiuri Paolo paolo.maiuri@ifom.eu ; and Paulina Nastaly\

IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy

Transmitting the cell polarity to the nucleus

19. Mullins Dyche R. dyche.mullins@ucsf.edu 

University of California, San Francisco, Howard Hughes Medical Institutes

Tel. 415-502-4838 

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20. O'Sullivan Justin justin.osullivan@auckland.ac.nz 

            The Liggins Institute, The University of Auckland, Auckland, New Zealand

Integrating multimorbidity into a whole of body understanding of disease using spatial genomics.

21. Percipalle Piergiorgio pp69@nyu.edu 

Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm SE-171 77, Sweden

The role of cytoskeletal proteins in genomic architecture during differentiation

22. Ruan Yijun Yijun.Ruan@jax.org 

The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA,

and Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA

Exploring the topological architecture in complex genetics of polygenic traits and diseases

23. Stein Gary S Gary.Stein@med.uvm.edu 

Department of Biochemistry and University of Vermont Cancer Center, Robert Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA

Epigenetic-mediated regulation of gene expression for biological control and cancer

24. Takizawa Takumi takizawt@gunma-u.ac.jp 

Department of Pediatrics, Graduate School of Medicine, Gunma University  

3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

Phone: +81-27-220-8203 / 8479

Nuclear architecture in the nervous system

25. Takashi Mikawa Takashi.Mikawa@ucsf.edu 

University of California San Francisco, Cardiovascular Research Institute, 555 Mission Bay Blvd South, MC3120, Room 352Z, PO Box 589001, San Francisco, CA 94158-9001

Office:415-476-3230. Lab:415-476-3231

Positioning of paternal and maternal chromosome sets

26. Tsuchiya Masa tsuchiya.masa@gmail.com 

Systems Biology Program, School of Media and Governance, Keio University, Fujisawa, Japan

Genomic Control Mechanism of Cell-Fate Changes

27. Ward Steven W. wward@hawaii.edu 

Institute for Biogenesis Research, Dept. Anatomy, Biochemistry & Physiology, Chief, Research Division Lakshmi Devi and Devraj Sharma Endowed Chair, Dept. OB/GYN and Women's Health John A. Burns School of Medicine, University of Hawaii at Manoa, 1960 East-West Rd. Honolulu, HI 96822 Tel:  808-956-5189

Functional Aspects of Sperm Chromatin Organization.

28. Uversky, Vladimir vuversky@usf.edu  NOT CONFIRMED

O autorze

Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Malgorzata Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital and the Adjunct Professor at Department of Genetics, University of Texas, M D Anderson Cancer Center.

Dr. Jacek Z. Kubiak is the Research Director (Full Professor) at the French CNRS in Rennes, France. His research is devoted to molecular mechanisms of early embryo development, cell cycle regulation, stem cells, cancer cells and the role of macrophages in the innate immune response. He is the author of 180 highly cited scientific articles and the editor or co-editor of 6 books. He has graduated from the Warsaw University, Poland and worked at the University of Wisconsin-Madison, USA and Marine Biological Laboratory in Woods Hole, USA. He collaborates with research institutes in Poland combining stem cells and cancer research with with the prospective in medical applications. Since the COVID-19 outbreak, he co-ordinates an international research group focused on SARS-CoV-2 infection in paediatric patients in WIM institute, Warsaw, Poland.