We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug...
We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal di...
Avoiding the hyperbole of past treatments of the subject, this book discusses maladies whose diagnoses are much different between males and females. Examples include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia.
Avoiding the hyperbole of past treatments of the subject, this book discusses maladies whose diagnoses are much different between males and females. E...
The environment of the fetus in the womb is emerging as a key determinant not only of its immediate status but also of the offspring's long-term well-being. This largely started with reports of striking epidemiological associations between lower, but still normal, birth weight and a marked increase in the incidence of cardiac, metabolic and neuropsychiatric disorders from childhood to senescence. In seeking to explain these observations, collectively referred to as developmental programming, ' a new subfield of biology has emerged. Major discoveries include detailing the etiological roles of...
The environment of the fetus in the womb is emerging as a key determinant not only of its immediate status but also of the offspring's long-term well-...
In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.
In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "...
This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, startingfrom genetic/molecular aspects, goingthrough structural/imaging changes and leading tophysical/behavioral characteristics. Therefore, renowned investigators involved in both animal and human researchsharedrecent dataas well asoverall appraisal of relevantquestionsaround CNS control of puberty and adolescence. No doubt that this volume will inspire those involved in either scientific research or clinical practice or both in the fascinating field of puberty and...
This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, startingfrom genetic/molecular as...
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field...
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, includ...
Obesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement. This volume provides insights into the biology of a complex endocrine organ: the adipose tissue.
Obesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue e...
Avoiding the hyperbole of past treatments of the subject, this book discusses maladies whose diagnoses are much different between males and females. Examples include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia.
Avoiding the hyperbole of past treatments of the subject, this book discusses maladies whose diagnoses are much different between males and females. E...
This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, starting from genetic/molecular aspects, going through structural/imaging changes and leading to physical/behavioral characteristics. Therefore, renowned investigators involved in both animal and human research shared recent data as well as overall appraisal of relevant questions around CNS control of puberty and adolescence. No doubt that this volume will inspire those involved in either scientific research or clinical practice or both in the fascinating field of puberty and...
This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, starting from genetic/molecular a...
This book is open access under a CCBY 4.0 licenseThe world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders.
This book is open access under a CCBY 4.0 licenseThe world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. Exerci...
