Albert M. Galaburda Stephen Michael Kosslyn Yves Christen
The only way we can convey our thoughts in detail to another person is through verbal language. Does this imply that our thoughts ultimately rely on words? Is there only one way in which thoughts can occur? This ambitious book takes the contrary position, arguing that many possible "languages of thought" play different roles in the life of the mind.
"Language" is more than communication. It is also a means of representing information in both working and long-term memory. It provides a set of rules for combining and manipulating those representations.
A stellar lineup of...
The only way we can convey our thoughts in detail to another person is through verbal language. Does this imply that our thoughts ultimately rely o...
Few people realize how much science can tell us about the differences between men and women. Yves Christen, provided the first comprehensive overview of research in this area when this classic book was first published in the1990s. He goes beyond simplistic "biology is destiny" arguments and constructs a convincing case for linking social and biological approaches in order to understand complex differences in behavior.
Biologists agree that the sexes differ in brain and body structure. Christen links these differences in cerebral anatomy to differences in behavior and intellect....
Few people realize how much science can tell us about the differences between men and women. Yves Christen, provided the first comprehensive overvi...
During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas biochemical pathology and molecular genetics combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative...
During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these ...
We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug...
We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal di...
Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the...
Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Gen...
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has...
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation...
Obesity is a disease of society and economic transition spreading at an epidemic pace throughout the world. According to the World Health Organization, obesity is defined as an increased or abnormal accumulation of body fat mass to the extent that individual's health will be negatively affected. Overweight is thus being considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders.This volume provides the most up to date insights into the biology of...
Obesity is a disease of society and economic transition spreading at an epidemic pace throughout the world. According to the World Health Organization...
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort...
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological syste...
Characterizing the computational architecture and neurobiological mechanisms underlying consciousness remains a major unsolved problem in cognitive neuroscience, but it has become an area of intense research. Thanks to new advances in stimulation paradigms, brain imaging techniques, and neuronal theorizing, the issue now appears to be empirically addressable. Yet a major challenge still confronts these novel empirical and theoretical proposals: will they be able to help clinicians confronted with patients in coma or vegetative state? Can they help define novel diagnostic or even...
Characterizing the computational architecture and neurobiological mechanisms underlying consciousness remains a major unsolved problem in cognitive...
