Inherited disorders of the kidney are becoming important, not only in pediatric nephrological practice, but also in adult nephrology, repres enting a high proportion of patients with end-stage renal failure. In almost 50% of all children and in 15% of adults accepted for renal rep lacement therapy, the causative disorders have a hereditary basis. Man y of these disorders are apparent at birth but may not cause renal fai lure until adolescence. Others may not appear until adult life. The co ntribution of these disorders to adult nephrological practice has so f ar been understated in most of...

This book respond to this interest by providing general information on the pathophysiology and clinical aspects of all types of amyloidosis. The recently discovered B2 type of dialysis amyloidosis, a serious co mplication which affects patients suffering from chronic renal failure, is fully covered from the clinical and pathological features to the p hysiological and pathophysiological aspects. This book will give nephr ologists and rheumatologists a clear understanding of the dialysis amy loidosis syndrome as well as making a valuable contribution to identif ying strategies for treatment and...

Many inherited diseases and non-herediatry disorders have in common th e development of renal cyctic disease. The most common, autosonal domi nant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the public ation six years ago of the last book on polycystic kidney disease, a n umber of genes causing the disease have been identified, mapped, or se quenced; new experimental models and the application of molecular biol ogy techniques have provided new insights into the pathogenesis of pol ycystic kidney disease; novel...

This volume aims to bring together current knowledge of both the scien tific and clinical aspects of RPN. Recent advances in the immunology, inflammatory mechanisms and pathology of RPGN are discussed. This is f ollowed by consideration of the major causes of RPGN, which include Go odpasture's disease, primary systematic vasculitis and systematic lupu s erythematosus. RPGN secondary to other renal and systemic diseases, and RPGN in children are also described. Finally, new approaches to tr eatment are reviewed. Although certain of these areas are covered in t he larger textbooks on renal...

As the dialysis population grows, the number of survivors in the second and even third decade of dialysis also increase. These long term survivors face not only the universal complications of dialysis such as anemia and hyparathyroidism but also the consequences of these complications such as the long term cardiovascular problems. They are also subjected to many years of accumulation of "uremic metabolites" resulting in conditions unique to this group of patients, the best example being dialysis amyloid. This book not only describes the causes of morbidity and mortality during the second...

This book describes the current status of vascular access for patients with end-stage renal failure who require dialysis. The book highlight s controversial areas and problems and describes differences in practi ce in USA and Europe.

Clinical nephrology is confronted with an emerging medical catastrophy of international proportions; endstage renal failure in patients with type 2 diabetes. Based on a number of recent studies it has become ap parent, that nephrology in type 2 diabetes is a preventable condition, at least in principle. It is for this reason that it appeared timely to summarize the current state of knowledge concerning nephropathy in type 2 diabetes giving an update on the predisposing factors on which interventions are of proven benefit and on the accepted standards of m anagement of such patients. This...

The goal of this text is to provide a comprehensive review of the path ophysiology and clinical manifestations of the principal cardiovascula r complications in patients with chronic renal failure. The text is in tended to assist nephrologists, cardiologists, and internists who care for these patients. The book includes nineteen chapters and is organi sed in three parts. The first includes three chapters dealing with the epidemiology of cardiovascular disease in patients with end-sage rena l failure. The second comprises eight chapters on the basic pathophysi ology and pathobiology of...