ISBN-13: 9780192625786 / Angielski / Twarda / 1996 / 608 str.
Many inherited diseases and non-herediatry disorders have in common th e development of renal cyctic disease. The most common, autosonal domi nant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the public ation six years ago of the last book on polycystic kidney disease, a n umber of genes causing the disease have been identified, mapped, or se quenced; new experimental models and the application of molecular biol ogy techniques have provided new insights into the pathogenesis of pol ycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the compl ications of this disease. This book provides an updated, state-of-the- art review of the genetics, pathophysiology, evaluation, and managemen t of these diseases and will be of interest to both basic researchers and clinicians in nephrology.