Many inherited diseases and non-herediatry disorders have in common th e development of renal cyctic disease. The most common, autosonal domi nant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the public ation six years ago of the last book on polycystic kidney disease, a n umber of genes causing the disease have been identified, mapped, or se quenced; new experimental models and the application of molecular biol ogy techniques have provided new insights into the pathogenesis of pol ycystic kidney disease; novel...