Zebrafish Models in Neurobehavioral Research encompasses a wide spectrum of the utility of zebrafish within neurobiological disciplines. Chapters provide authoritative reviews of zebrafish paradigms commonly used in the field today.
Zebrafish Models in Neurobehavioral Research encompasses a wide spectrum of the utility of zebrafish within neurobiological disciplines. Chapters prov...
This authoritative book investigates a wide range of pain mechanisms. It seeks to lead scientists closer to the ultimate goal of improving the quality of life and relieving the unbearable burden of chronic pain for millions of people throughout the world.
This authoritative book investigates a wide range of pain mechanisms. It seeks to lead scientists closer to the ultimate goal of improving the quality...
In this provocative and cutting-edge book, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with those used in humans. The chapters provide authoritative reviews of many commonly used approaches in the field.
In this provocative and cutting-edge book, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with t...
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal...
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models ...
The development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological research is performed in the modern laboratory. In Photosensitive Molecules for Controlling Biological Function, expert researchers in the field examine the most cutting-edge tools currently available. Divided into three sections, this detailed compendium features techniques involving natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow light sensitivity on ion channels and receptors....
The development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological r...
Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi). To date, hundreds of conserved and species-specific microRNAs have been identified in organisms ranging from single-celled algae to humans. Many of these tiny RNAs are now known to play fundamental roles in developmental biology and disease pathogenesis. In addition, RNAi has emerged as a technology useful for manipulating gene expression. In "RNA Interference Techniques," expert researchers present detailed methods for designing and...
Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi)...
In the past few years, the application of proteomics to examine the molecular mechanisms underlying (mal-)functioning of the nervous system and brain disorders has risen steeply, which in many cases has yielded novel insights. As neuroproteomics is a new research field involving the use of a number of high-end analytical instruments and technologies, both promises and pitfalls may not be well appreciated by the researchers, and the design of a proper proteomics experiment may not be obvious. Neuroproteomics brings together a collection of detailed protocols written by experienced...
In the past few years, the application of proteomics to examine the molecular mechanisms underlying (mal-)functioning of the nervous system and bra...
Continuing the research of the best-selling first edition, Patch-Clamp Analysis: Advanced Techniques, Second Edition collects three more years of research in the ever-expanding study of the cell membrane. With the latest developments in the traditional patch techniques such as whole-cell and single channel as well as perforated patch, fast drug application, loose patch and macropatch techniques, this authoritative second edition updates the standard techniques while introducing three brand new, cutting-edge technical advances in the field.
Thorough and timely, Patch-Clamp Analysis:...
Continuing the research of the best-selling first edition, Patch-Clamp Analysis: Advanced Techniques, Second Edition collects three more years of r...
Neuropeptides exhibit multiple functions as hormones and regulators. As such, many techniques are required to understand the contribution and functions of neuropeptides in health and disease processes. Research in the neuropeptide field is aimed toward a better understanding of the physiology of the human body and toward the development of better diagnostics and therapeutics. This book will familiarize the audience with forefront techniques in the field.
Neuropeptides exhibit multiple functions as hormones and regulators. As such, many techniques are required to understand the contribution and funct...
In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms...
In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neur...
