The objective of the new series, "Molecular Biology, Biochemistry and Biophysics," of which this brochure forms the first volume, is to produce more than another compilation of data. It is hoped that the new series will help the individual "specialist" keep abreast of important developments in the natural sciences at the molecular and subcellular level in fields complementary to his own. The predominant aim is not so much to increase the ever-growing body of information in an encyclopedic fashion but rather to give, in addition to a well- rounded factual presentation of subjects which have...

This book deals with energetics of transport processes, largely expressed in terms of the thermodynamics of irreversible pro cesses. Since at the present time too little is known about the molecular mechanism of transport, the present treatment is based largely on hypothetical models. Care has been taken, however, to define the crucial features of these models as generally as pos sible, so that the equations do not depend too much on hypotheti cal details. Accordingly, most equations, though developed on the basis of a mobile carrier (ferryboat) model, should apply equally to a conformational...

Among terrestrial plants the vascular plants are the largest and the most con- spicuous. Because of the presence of lignified supporting and conducting tissues such as xylem, terrestrial vascular plants can develop large upright forms. Composed mainly of xylem tissue, the stems of trees are characterized by elongated cells with thickened walls, impregnated by lignin. Diagrams of xylem cells (vessels, tracheids and fibers) can be seen in textbooks of plant anatomy (e. g. ESAU, 1953). A cross section of xylem tissue is shown in the section of this volume written by Professor FREUDENBERG (Fig....

This monograph is neither a historical outline of the development of the concepts of protein biosynthesis and the structure and functions of the ribosomes, nor an exhaustive survey of the literature on these questions. The monograph is based upon an analysis of the modern trends in this field. The purpose of the monograph was to formulate more or less generalized representations of the structure and" function of the ribosome, as we envision it at the present day. It may be that this attempt is premature for a number of reasons, and the concepts outlined here will very soon be revised....

It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms is a fascinating problem of bio-medical importance. The functional heterogeneity of reactions mediated by immunoglobulins-is remarkable, ranging from protection against life-threatening toxins and microbes to the production of laryngeal edema...

In recent years bacteriocins, especially colicins, have become widely known to molecular biologists as proteins with peculiar ways of killing bacteria. These same bacteriocins have been known for a long time to bacteriology for their unusual activity spectra and enormous variety. In this monograph I have attempted to bring together our detailed knowledge of those few bacteriocins which have already re ceived attention from molecular biologists, and our less detailed hut extensive knowledge of the variety of bacteriocins which exist. The field has been reviewed in whole or in part, by several...

A century has already passed since FRIEDRICH MIESCHER, working at Strasbourg and Basel, began his study of protamine, one of the basic nuclear proteins of cells. It was first established by KOSSEL that protamine represents the simplest known protein. In the conviction that research into the nature of protamine would shed light on that of other typical proteins, a group of researchers in Germany followed MIESCHER and laid the foundations of protein chemistry. A general view of prot amines was thus built up by KOSSEL, working at Strasbourg, Berlin, Marburg an der Lahn, and Heidelberg, FELIX at...

This book had its origins in some conversations held several years ago. It was felt that a monograph on the subject of tissue specificity might have some merit and interest for a number of scientific workers in the relevant disciplines. Writing was begun slowly, with interruptions; more recently, there has been much more activity, and the relevant literature has been searched and cited up to early 1973. This book was never intended as an exhaustive coverage of all possible topics related to tissue specificity. The tissues and organs covered in six chapters constitute a selected group,...

Approximately one third of the mass of a mammalian red blood cell is hemo globin. Its major function is to bind oxygen at the partial pressure prevailing in the lungs and to release it to the tissues where the partial pressure is lower. The process whereby hemoglobin performs this essential physiological role is characterized by a cooperative interaction among its constituent subunits. A great deal of research effort has been devoted to this interaction, going back at least as far as the fitst decade of this century. Moreover, cooperativity in hemo globin is probably not unique; it may well...

This book presents a distillation of many years of investigation by the author and his associates on the problem of sensory reception. Both our own data and data from the scientific literature on the electron microscopy, cytochemistry, biochemistry and electrophysiology of the organs of vision, taste, smell, hearing and gravitation, are presented to show that the evolution of the sense organs of all animals on our planet is based on a receptor cell equipped with a motile antenna, a biological recorder of information concerning certain types of energy reaching the animal from the environment....