This is the second of three volumes of Methods in Molecular Biology that deal with Physical Methods of Analysis. The first of these, Spectroscopic Methods and Analyses dealt with NMR spec- troscopy, mass spectrometry, and metalloprotein techniques, and the third will cover X-ray crystallographic methods. As with the first volume. Microscopy, Optical Spectroscopy, and Macroscopic Techniques is intended to provide a basic understand- ing for the biochemist or biologist who needs to collaborate with spe- cialists in applying the techniques of modern physical chemistry to biological...

A unique guide to variable temperature CD spectroscopy and its application in organic chemistry
This timely, original, thought-provoking work looks at organic stereochemistry from the perspective of circular dichroism (CD), using variable temperature CD spectroscopy to determine the conformation or absolute configuration of chiral molecules. With an emphasis on the analysis of optically active ketones and the carbonyl chromophore, the authors demonstrate the advantages of this highly sensitive spectroscopic tool for obtaining stereochemical information in diverse areas of organic...

Molecules are held together by chemical bonds. The CH-( interactions deals with the interactions between two bonds, which contributes to the shape and reactivity of the molecule. This book presents an overview of the experimental basis, theoretical background, and nature of the CH-( Interactions. The CH-( Interaction refers to a weak attractive force that originally was inferred from structural data obtained by spectroscopy. The characteristics of this weak force are compared to those of other hydrogen bonds.

The various techniques used to analyze the microstructures of polymers are presented in this book. High resolution and solid state techniques are described, and applications to both synthetic and biological polymers are discussed in detail.

Particular emphasis is placed on the determination of polymer microstructure by NMR spectroscopy. Here attention is drawn to the connection between the microstructures and NMR spectra of polymers, and it is demonstrated that the local polymer conformation provides this link. The numerous examples illustrating this connection are a special...

The fields of structural chemistry and biochemistry have blossomed in the last seventy years since X-ray diffraction was discovered in 1912. Dorothy Hodgkin, who obtained a Nobel Prize in 1965 for her X-ray diffraction work wrote 'a great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure with, at the same time, complete certainty.' The results of all X-ray diffraction studies are used by chemists and buiochemists but these scientists need to be able to appreciate the significance and extent to which...

An authoritative review of the state of the art in the Nuclear Overhauser Effect-essential information for organic chemists, biochemists, biophysicists, and NMR spectroscopists
The field of NMR spectroscopy has seen tremendous growth in the last twenty years, particularly advances relating to Nuclear Overhauser Effect (NOE) spectroscopy-the most powerful technique for obtaining structural information on molecules in solution. Extensive and engaging, the Second Edition of the leading reference on the NOE is significantly updated to reflect the latest changes and new approaches in the...

Since 1990, advances in laser spectroscopy have made it possible to selectively excite and follow the fate of a single molecule with ultrafast resolution. This has made it possible to monitor the elementary processes that occur directly after absorption of a photon. This volume focuses on the conformational changes in organic molecules that result from absorption of a photon. These include those accompanying intramolecular excited state electron transfer, intra- and intramolecular excited state proton transfer, photoisomer formation, exciplex formation and control of photoproduct formation.

Most books on organic conformational deal with sterochemistry, while neglecting the spatial structure of organic molecules, especially the unusual ones. This ambitious monograph presents a global view of organic structure and conformational analysis in a very readable style. The author's fascination with the beauty and variety of shapes of organic molecules comes through in her description of the importance of molecular organization in organic chemical and biological systems, the quantum foundations of molecular spatial structure, molecular symmetry, chiralty and physical methods for studying...

Here is an in-depth presentation of current research and theory on the chemistry of three-dimensional polycyclic molecules, or 'cage molecules, ' synthesized compounds with closed structures. Internationally known scientists introduce their areas of expertise, ranging from general principles to highly specialized perspectives on this fascinating branch of pure chemistry

This collection of twenty-six articles by leading experts is the first truly comprehensive account of the gas-phase electron diffraction technique. It is written for the non-specialist users of structural information.

Part A discusses the development and present capabilities of gas electron diffraction. Several contributions deal with the combined application of various techniques. Part B contains the structural information and also presents trends and interpretations of structural variations.