A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. DNA Arrays: Technologies and Experimental Strategies offers a view of different aspects of this rapidly developing technology, including oligonucleotide and electrochemical arrays. Distinguished investigators from academia and industry provide up-to-date insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization...
A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simu...
This text is a volume in the Methods and New Frontiers in Neuroscience series. Initally confined to behavioural studies, the field of drug addiction and substance abuse has broadened dramatically to include a vast array of cellular and molecular approaches as well as sophisticated electrophysiological, neurochemical, and imaging methodologies. This text assembles this information, providing detailed descriptions of proceedures as well as methods and equipment used to conduct experiments that use multiple technical approaches. Topics include: brain reward mechanisms in the addictive process;...
This text is a volume in the Methods and New Frontiers in Neuroscience series. Initally confined to behavioural studies, the field of drug addiction a...
Nicotine research has been conducted for the better part of a century, but with the discovery of the relationship of nicotinic systems to Alzheimer's disease, the differentiation of nicotinic receptor subtypes, and the development of novel nicotinic ligands, the field of nicotine research has exploded. This book will provide you reference to the latest research methods and findings concerning nicotinic neural systems. Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of cutting-edge research concerning neuronal nicotinic systems relevant...
Nicotine research has been conducted for the better part of a century, but with the discovery of the relationship of nicotinic systems to Alzheimer's ...
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable scope are now being routinely solved in neuroscience and many other areas of biomedical research. The results of these studies, in turn, are having, and will continue to have, profound impact on experimental approaches and designs for manipulating...
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and r...
Presents the State-of-the-Art in Fat Taste Transduction
A bite of cheese, a few potato chips, a delectable piece of bacon a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the sensory appeal of foods rich in fat. This well-researched text uses a multidisciplinary approach to shed new light on critical concerns related to dietary fat and obesity.
Outlines...
Presents the State-of-the-Art in Fat Taste Transduction
A bite of cheese, a few potato chips, a delectable piece of bacon a...
In 1993, the genetic mutation responsible for Huntington s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene.
Neurobiology of Huntington s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and...
In 1993, the genetic mutation responsible for Huntington s disease (HD) was identified. Considered a milestone in human genomics, this discovery ha...
One of the Most Rapidly Advancing Fields in Modern Neuroscience
The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone...
One of the Most Rapidly Advancing Fields in Modern Neuroscience
The success of molecular biology and the new tools derived...
It has become accepted in the neuroscience community that perception and performance are quintessentially multisensory by nature. Using the full palette of modern brain imaging and neuroscience methods, The Neural Bases of Multisensory Processes details current understanding in the neural bases for these phenomena as studied across species, stages of development, and clinical statuses.
Organized thematically into nine sub-sections, the book is a collection of contributions by leading scientists in the field. Chapters build generally from basic to applied,...
It has become accepted in the neuroscience community that perception and performance are quintessentially multisensory by nature. Using the full pa...
The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is released in close proximity to glutamate. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of these two neurotransmitters, dopamine and glutamate.
Elucidating the relationship between their molecular...
The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicat...
An up-to-date look at the role of astrocytes in CNS function and dysfunction, this volume emphasizes the capacity of astrocytes for diverse cellular connection and the resulting implications.
An up-to-date look at the role of astrocytes in CNS function and dysfunction, this volume emphasizes the capacity of astrocytes for diverse cellular c...
