Translational Pain Research: From Mouse to Man

ISBN-13: 9781439812099 / Angielski / Twarda / 2009 / 456 str.

Lawrence Kruger;Alan R Light

Opis

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on:

• Nociceptor sensitization
• Muscle nociceptors and metabolite detection
• Visceral afferents in disease
• Innovative rodent model for bone cancer pain
• Highly specific receptor cloning
• Modular molecular mechanisms relevant to painful neuropathies

This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, this book examines rodent models for pain associated with bone cancer, osteoarthritis, and cardiac episodes. It covers the cloning of highly specific receptors and the analysis of modular molecular mechanisms relevant to painful neuropathies, while also considering the bearing of this trend toward translational research on the commercial pharmaceutical establishment.

Recenzje

As the editors of Translational Pain Research: From Mouse to Man state in their preface, "the study of pain is of enormous human importance for the obvious reason that in the course of a lifetime, few individuals manage to evade disruption of their lives by consequential pain experiences." The book is a comprehensive survey of recent pain research that attempts to bring basic science closer to the bedside. The primary intended audience of the book is academic and pharmaceutical industry researchers. Laboratory animal veterinarians and research technicians will also find it a useful reference…In conclusion, Translational Pain Research is a comprehensive review of current research in an area of vital interest to laboratory animal professionals responsible for programs in experimental pain research. The book is highly technical but a non-specialist would find it difficult, but ultimately rewarding.
--Journal of the American Association for Laboratory Animal Science, September 2010

Spis treści

Painful Multi-Symptom Disorders: A Systems Perspective. Neurotrophic Factors and Nociceptor Sensitization. The Role of Visceral Afferents in Disease. Cancer Pain: From the Development of Mouse Models to Human Clinical Trials. Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States. Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes. Transgenic Mouse Models for the Tracing of "Pain" Pathways. Cytokines in Pain. Glial Modulation in Pain States: Translation into Humans. On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain. Myalgia and Fatigue: Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes. Reflex Autonomic Responses Evoked by Group III and IV Muscle Afferents. Central Pain as a Thalamocortical Dysrhythmia: A Thalamic Efference Disconnection? What Can Neuroimaging Tell Us about Central Pain? Human Brain Imaging Studies of Chronic Pain: Translational Opportunities. Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs. Large Animal Models for Pain Therapeutic Development. Drug Discovery and Development for Pain. Index.