Synthesizing current information about sensory-motor plasticity, Neural Plasticity in Adult Somatic Sensory-Motor Systems provides an up-to-date description of the dynamic processes that occur in somatic sensory-motor cortical circuits or somatic sensory pathways to the cortex due to experience, learning, or damage to the nervous system. The book emphasizes changes in the cortex that are linked to shifts in movement or behavior and demonstrates the potential for direct brain-based interventions to improve the quality of life for people with sensory-motor disabilities.
Following initial...

Exploring the diverse tools and technologies used to study synaptic processes, The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology delineates techniques, methods, and conceptual advances for studying neurotransmitter receptors and other synaptic proteins. It describes a broad range of molecular, biochemical, imaging, and electrophysiological approaches for studying the biology of synapses.

Specific topics include the use of proteomics to study synaptic protein complexes, the development of phosphorylation state specific antibodies, post-genomic...

The costs associated with a drug s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans.

Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction,...

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from leading experts in their fields, the book explores serotonin receptors from a broad-based, multidisciplinary approach. The approaches described vary from molecular biological techniques to fluorescence microscopy and imaging, to genetic manipulation...

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels.
While no single book could...

Providing an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain.
Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the...

A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniques have been used to investigate how cellular and brain circuits may be modified by experience. In each chapter, researchers present findings and explain their innovative methodologies.
The book begins by introducing key issues and providing a...

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field."

With each topic presented by one or more of the leading experts in the field, it examines the major modern techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The materi al also covers conventional methods of pain study, such as anatomical and electophysiological techniques. Methods in Pain Research provides up-to-date methodology and a guide to the strategies of experimental d esign.

A volume in the Methods and New Frontiers in Neuroscience series, this package is designed primarily as an introduction to realistic modelling methods, focusing on: understanding neuronal modelling techniques; methodological approaches; selecting appropriate methods; and identifying potential pitfalls. The inclusion of a CD-ROM furnishes interactive modelling examples.