This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery, complemented by an extensive list of references to the...
This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institut...
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders are also actively pursued.
This book...
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions th...
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause...
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavi...
Systems biology represents the integration and application of various technologies that share a common goal of measuring globally the properties of a specific biological sample. These combined data describe and monitor the complex networks that exist within each cell, tissue and organism, and can be used to generate predictive models of the behavior of the system. This volume aims to provide a timely view of the "state of the art" in systems biology. The editors take the opportunity to define systems biology as they and the contributing authors see it, and this will lay the groundwork for...
Systems biology represents the integration and application of various technologies that share a common goal of measuring globally the properties of...
Molecular Toxicology is the first volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and...
Molecular Toxicology is the first volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-...
Molecular, Clinical and Environmental Toxicology offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals during daily life all over the world. About 29 million different organic and inorganic compounds are currently listed in the Chemical Abstract Service (CAS) database and there are additions almost every day. The present volumes have been written for students and professionals in medicine, science, public health or engineering who are demanding reliable information and knowledge on toxic or potentially harmful agents and their effects in the...
Molecular, Clinical and Environmental Toxicology offers a comprehensive and in-depth response to the increasing importance and abundance of chemica...
This overview of galanin research shows how the identification, isolation and characterization of this peptide was brought about and how its functionality was revealed as the pharmacological tools to dissect galaninergic mechanisms were developed.
This overview of galanin research shows how the identification, isolation and characterization of this peptide was brought about and how its functiona...
This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods.
The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and...
This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identifica...
Der bei allen Saugetieren vorkommende Gebarmutterhals, als Abschluss der Ge barmutterhohle gegenuber dem Scheidenraum definiert, zeichnet sich beim Rinde durch einen besonders komplizierten Bau aus. Sein anatomischer und histologischer Aufbau wird anband der Literatur beschrieben und die hormo nellen und nervosen Einflusse, welche seine Funktion steuern, besprochen. Das funktionelle Verhalten der Cervix uteri des Rindes wird wahrend Brunst, Dioestrum, Trachtigkeit und Geburt im einzelnen geschildert. Da uber die Invo lution der Cervix im Anschluss an die Geburt nur altere Literaturangaben...
Der bei allen Saugetieren vorkommende Gebarmutterhals, als Abschluss der Ge barmutterhohle gegenuber dem Scheidenraum definiert, zeichnet sich beim Ri...
J. M. Polak and S. R. Bloom For some time Experientia has published, as a unique feature, interdis ciplinary multi-author reviews, giving a comprehensive overview of sub jects regarded as 'growing edges' of science. The enthusiasm shown by the readers was contagious and thus it was felt necessary to compile a special volume dealing with the novel aspects of regulatory peptides. This book covers some of the growing areas in regulatory peptide research and, although it is based on the original volume of Experientia, it is expanded and updated. The topic of 'regulatory peptides' is relatively...
J. M. Polak and S. R. Bloom For some time Experientia has published, as a unique feature, interdis ciplinary multi-author reviews, giving a comprehens...
