Galanin

ISBN-13: 9783034602273 / Angielski / Twarda / 2010 / 286 str.

Tomas Hakfelt

Opis

This overview of galanin research shows how the identification, isolation and characterization of this peptide was brought about and how its functionality was revealed as the pharmacological tools to dissect galaninergic mechanisms were developed.

Spis treści

Galanin - a multitalented neuropeptide.- Galanin, galanin receptors and drug targets.- Galanin acts as a trophic factor to the central and peripheral nervous systems.- Galanin and spinal pain mechanisms: past, present and future.- Galanin family of peptides in skin function.- Galanin in glia: expression and potential roles in the CNS.- Galanin and the neuroendocrine axes.- Galanin and consummatory behavior: Special relationship with dietary fat, alcohol and circulating lipids.- Neurochemical modulation of central cardiovascular control. The integrative role of galanin.- Galanin impairs cognitive abilities in rodents: Relevance to Alzheimer’s disease.- Neuroprotective role for galanin in Alzheimer’s disease.- Galanin, galanin receptor subtypes and depression-like behaviour.- Galanin and epilepsy.- Galanin and addiction.- Galanin systems and ischemia: peptide and receptor plasticity in neurons and oligodendroglial precursors.- The galanin system in cancer.- Galanin systems in non-mammalian vertebrates with special focus on fishes.- Galanin-like peptide (GALP): Neural regulator of energy homeostasis and reproduction

Blurb

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.