The past 50 years have witnessed a breathtaking evolution in the approaches to the patient with an acute ST elevation myocardial infarction. In the 1960s, the now commonplace cardiac intensive care unit was but a nascent idea. Without much to offer the patient but weeks of absolute bedrest, substantial morbidity and high rates of mortality were the norm. Just 30 years ago, seminal discoveries by DeWood and colleagues suggested that the culprit was plaque rupture with thrombosis, not progressive luminal compromise. Subsequent fibrinolyt- based strategies resulted in a halving of the mortality...
The past 50 years have witnessed a breathtaking evolution in the approaches to the patient with an acute ST elevation myocardial infarction. In the 19...
Challenges for the treatment of valvular heart disease include the development of effective yet less invasive interventions and therapies to treat and ease the progressive nature of such conditions. With prospective new treatments, it is crucial for cardiac physicians to keep abreast of the latest advances and newest therapeutic options, surgical risk assessment, surgical techniques, and outcomes. Written by a highly respected and internationally recognized group of cardiologists, cardiac surgeons, and researchers, Valvular Heart Disease offers insights into the widely varying hemodynamic and...
Challenges for the treatment of valvular heart disease include the development of effective yet less invasive interventions and therapies to treat and...
Cardiovascular heart disease mortality in African Americans is the highest of all major racial/ethnic populations in the US. Examining race & ethnicity, this volume will reveal that there are unacceptable healthcare disparities in risk factor prevalance, disease states, & cardiovascular outcomes.
Cardiovascular heart disease mortality in African Americans is the highest of all major racial/ethnic populations in the US. Examining race & ethnicit...
Peripheral and Cerebrovascular Intervention draws upon experts from diverse fields to provide readers with a comprehensive foundation for understanding and performing endovascular procedures--from the basic steps to the most current and advanced techniques. Individual chapters focus on primary intervention sites, including lower extremity, renal/mesenteric, subclavian/upper extremity, carotid/vertebral, intracranial and venous interventions. Additionally, chapters covering critical limb ischemia and abdominal and thoracic aortic aneurysms are included. By incorporating...
Peripheral and Cerebrovascular Intervention draws upon experts from diverse fields to provide readers with a comprehensive foundation...
Experimental and clinical evidence supports the view that the activation of the renin angiotensin aldosterone system is involved in cardiovascular pathology including hypertension, heart failure, myocardial ischemia, and atherosclerosis. The present volume describes the intricacies involved in these processes, including the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7), and aldosterone on cardiac and vascular functions as well as their involvement in the generation of cardiovascular diseases. Fundamental aspects like intracellular signaling, regulation of cell volume in the...
Experimental and clinical evidence supports the view that the activation of the renin angiotensin aldosterone system is involved in cardiovascular pat...
Heart failure affects over 5 million patients in the United States alone. In this book, a panel of authorities on the use and implementation of device based therapies provide an overview of the current and developing technologies used to treat heart failure.
Heart failure affects over 5 million patients in the United States alone. In this book, a panel of authorities on the use and implementation of dev...
Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the...
Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to...
In 1962, Thomas Kuhne coined the term paradigm shift while arguing that human knowledge advances by quantum leaps with interspersed smaller steps. Preparation for the major advance is generally not a concerted effort by thought leaders. Rather, a few (or one) visionaries gain insights into a process and are able to definitely demonstrate the accuracy of their worldview. Often, the epiphany does not occur during the intellectual lifetime of the discoverers. Medicine has had numerous such paradigm shifts including the compelling reworking of Galen s concepts of the body. Of note, the scientific...
In 1962, Thomas Kuhne coined the term paradigm shift while arguing that human knowledge advances by quantum leaps with interspersed smaller steps. Pre...
Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more...
Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-...
This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the past decade. The discoveries of endothelin overexpression as well as prostacyclin and nitric oxide deficiency in association with pulmonary hypertension have led to important therapeutic insights. The new therapies have led to significant improvements in patient function, quality of life and survival. In this book, expert authors describe these new therapies. It will be of interest not only to cardiologists, pulmonary specialists and...
This timely volume addresses the areas of pathophysiology and therapy of pulmonary hypertension, which have seen exciting developments over the pas...
