Renin Angiotensin System and Cardiovascular Disease

ISBN-13: 9781607611851 / Angielski / Twarda / 2009 / 300 str.

Walmor C. Demello; Edward D. Frohlich

Opis

Experimental and clinical evidence supports the view that the activation of the renin angiotensin aldosterone system is involved in cardiovascular pathology including hypertension, heart failure, myocardial ischemia, and atherosclerosis. The present volume describes the intricacies involved in these processes, including the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7), and aldosterone on cardiac and vascular functions as well as their involvement in the generation of cardiovascular diseases. Fundamental aspects like intracellular signaling, regulation of cell volume in the failing heart, and the presence of an intracrine renin angiotensin system are discussed. Moreover, the role of the mineralocorticoid receptor as an important c- ponent of the intracrine renin angiotensin system and as a regulator of extracellular action of angiotensin II is described, reinforcing the view that aldosterone inhibitors are helpful in the treatment of heart failure and hypertension. Let us hope the imp- tant topics included here motivate basic and clinical investigators and contribute to the development of new therapeutic approaches for cardiovascular diseases. We want to thank the distinguished authors and Humana Press for the opportunity to publish this important book. Walmor C. DeMello Edward Frohlich v Contents 1 Systemic Versus Local Renin Angiotensin Systems. An Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Walmor C. DeMello and Richard N. Re 2 Clinical Import of the Local Renin Angiotensin Aldosterone Systems . . . . . . . . . . . . . . . . . . . . . . . . . 7 Edward D. Frohlich 3 Renin, Prorenin, and the (Pro)Renin Receptor . . . . . . . . . . . 15 Genevieve Nguyen and Aurelie Contrepas 4 Local Renin Angiotensin Systems in the Cardiovascular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Richard N.

Spis treści

Systemic Versus Local Renin Angiotensin Systems: An Overview Walmor C De Mello, MD and Richard N Re, MD Clinical Importance of the Local Renin-Angiotensin aldosterone Systems Edward D. Frohlich, MD Renin, Prorenin And The (Pro)Renin Receptor Genevieve Nguyen and Aurelie Contrepas Local Renin-Angiotensin Systems in the Cardiovascular System Richard N Re, MD Renin-Angiotensin-Aldosterone System and Pathobiology of Hypertension Pierre Paradis, MD and Ernesto L. Schiffrin, MD At1 Receptors, Angiotensin Receptor Blockade and Clinical Hypertensive Disease Robert M. Carey, M.D., M.A.C. P Structural and Electrophysiologic Remodeling of the Failing Heart. On the Role of the Renin Angiotensin Aldosterone System Walmor C De Mello, MD Inhibiting the Renin Angiotensin Aldosterone System in Patients with Heart Failure and Myocardial Infarction Marc A. Pfeffer, M.D., Ph.D Left Ventricular Hypertrophy and Treatment With Renin-Angiotensin System Inhibition Edward D. Frohlich, MD and Javier Díez, MD, PhD Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and New Components of the Renin-Angiotensin System Aaron J. Trask, Jasmina Varagic, Sarfaraz Ahmad, Carlos M. Ferrario Kinin Receptors and ACE Inhibitors: an Interrelationship Ervin G. Erdös, MD, Fulong Tan, PhD and Randal A. Skidgel, PhD Kinins and Cardiovascular Disease Oscar A. Carretero, M.D., Xiao-Ping Yang, MD, Nour-Eddine Rhaleb, PhD, FAHA CMS and Type 2 diabetes Mellitus: Bound together by the Renin-Angiotensin-Aldosterone System Deepashree Gupta, MD, Guido Lastra, MD, Camila Manrique, MD, James R Sowers, MD Renin Angiotensin Aldosterone System and CardiovascularDisease Swynghedauw Bernard, Milliez Paul, Messaoudi Smail, Benard Ludovic, Samuel Jane-Lise, Delcayre Claude Renin Angiotensin System and Atherosclerosis Changping Hu, Jawahar L. Mehta Renin Angiotensin System and Aging León F. Ferder MD

Blurb

The renin angiotensin system plays an essential role on cardiac and vascular functions and their connection in the generation of cardiovascular diseases. Renin Angiotensin System and Cardiovascular Disease covers indispensable aspects such as intracellular signaling, regulation of cell volume in the failing heart, the presence of an intracrine renin angiotensin system, and the influence of prorenin/renin, angiotensin II, angiotensin (1-7) and aldosterone. Furthermore, the role of the mineralocorticoid receptor as an imperative component of the intracrine renin angiotensin system and as a regulator of extracellular action of angiotensin II is described, reinforcing the view that aldosterone inhibitors are helpful in the treatment of heart failure and hypertension. Renin Angiotensin System and Cardiovascular Disease provides readers with an outstanding review of the major topics involving the renin angiotensin system and cardiovascular disease. With contributions by an international panel of experts, Renin Angiotensin System and Cardiovascular Disease presents the most relevant aspects of the role of the renin angiotensin aldosterone system on cardiovascular diseases including hypertension, congestive heart failure, atherosclerosis and diabetes. The volume Editors, Dr. Walmor C. DeMello and Dr. Edward Frohlich, both established specialists in their respective fields, team up to discuss a range of topics from Renin Angiotensin Aldosterone System and Pathobiology of Hypertension to Inhibiting the Renin Angiotensin Aldosterone System in Patients with Heart Failure and Myocardial Infarction.