Stem Cells and Myocardial Regeneration

ISBN-13: 9781617377051 / Angielski / Miękka / 2010 / 400 str.

Marc S. Penn

Opis

Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.

Spis treści

Stem Cells and Myocardial Regeneration Table of Contents 1. The Challenge for Stem Cell Therapy: Overview of the Problem: Heart Attack and Heart Failure Marc S. Penn, MD, PhD Eric J. Topol, MD Cleveland Clinic Foundation Cells of interest for myocardial regeneration 2. Hematopoietic Stem Cells for Myocardial Regeneration Don Orlic, PhD Richard O. Cannon III, M.D. National Institutes of Health 3. Mesenchymal Stem Cells for Cardiac Therapy Mark F. Pittenger, PhD Osiris Therapeutics, Inc 4. Multipotent Adult Progenitor Cells Wouter van't Hof Niladri Mal Amy Raber Ming Zhang Anthony Ting Marc S. Penn Robert Deans Athersys 5. Mesenchymal Progenitor Cells for Vascular Formation and Cardiac Muscle Regeneration Silviu Itescu MD Fiona See PhD Timothy Martens MD Columbia University 6. Umbilical Cord Blood Stem Cells for Myocardial Regeneration and Angiogenesis Shyam Bhakta, MD Mary Laughlin, MD Case Western Reserve University 7. Endogenous Cardiac Stem Cells Elisa Messina Alessandro Giacomello Eduardo Marban University of Rome 'La Sapienza' & Johns Hopkins University 8. Embryonic Stem Cells for Myocardial Repair Lior Gepstein, MD, PhD Technion, Israel Mechanisms and critical pathways involved in myocardial repair 9. Chemokine and Homing Factor Expression in Acute Myocardial Infarction and Congestive Heart Failure Arman T. Askari, MD Marc S. Penn, MD, PhD Cleveland Clinic Foundation 10. Stem Cell Differentiation Towards a Cardiac Myocyte Phenotype Andrea Ladd, PhD Cleveland Clinic Foundation 11. Electrical Coupling and/or Ventricular Tachycardia Risk of Cell Therapy Shuixiang Yang MD Dayi Hu, MD, PhD Beijing, China 12. Cell Therapy for Myocardial Damage: Arrhythmia Risk and Mechanisms William R. Mills, MD Kenneth R. Laurita, PhD MetroHealth Campus, Case Western Reserve University Strategies for Cell Delivery advantages/disadvantages 13. Aspects of Percutaneous Cellular Cardiomyoplasty Matthew Hook, MD Patrick Whitlow, MD Cleveland Clinic Foundation 14. Open-Chest / Minimally Invasive Surgical Techniques Roberto Lorusso MD, PhD Josè L. Navia, MD Cesare Beghi°, MD Fernando A. Atik, MD Cleveland Clinic Foundation, Brescia and Parma, Italy Stem Cell Based Clinical Trials for Cardiac Dysfunction 15. Measures of Effective Cell Based Therapies Wael A. Jaber, MD Manuel Cerqueira, MD Cleveland Clinic Foundation Congestive Heart Failure 16. Whole Bone Marrow Transplantation Emerson C. Perin, MD Guilherme V. Silva, MD Texas Heart Institute 17. Clinical Angioblast Therapy Amit N. Patel, MD, MS Jorge Genovese, MD University of Pittsburgh Medical Center 18. Use of skeletal myoblasts for the treatment of CHF Anthony W. Ashton David D'Alessandro Robert E. Michler Albert Einstein College Acute MI 19. Bone Marrow and Angioblast Transplantation Marc S. Penn, MD, PhD Samuel Unzek, MD Niladri Mal, MD Kai Wang, MD, PhD Cleveland Clinic Foundation 20. Strategies for Cytokine Modification and Stem Cell Mobilization Stephen G. Ellis, MD Brian J. Bolwell, MD Cleveland Clinic Foundation Summary/Future Challenges 21 Summary and Future Challenges Marc S. Penn, MD, PhD Cleveland Clinic Foundation