In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. Since then, with the help of a growing number of investigators, knowledge about the biology of "the worm" has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. The past few years have seen the completion of two major long-term...
In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and...
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of...
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trill...
Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomes comprises a collection of review articles reprinted from the 10th Anniversary issue of the journal Genome Research that capture the status of genomic research in a selection of model species--from microbes to human. Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research. Topics addressed include gene regulatory...
Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Gen...
George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize Swinning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This is the first biography of a giant of genetics, written by two of the field's most distinguished contributors, Paul Berg...
George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. A...
The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and...
The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this ex...
Continuing his exploration of popular American culture, Schroeder investigates how the front yard came to be, with its clipped lawns, shaped bushes, conventional flowers, noble shade trees, sidewalk frames, and other elements denoting respectability. He notes that it came into being between 1870 and
Continuing his exploration of popular American culture, Schroeder investigates how the front yard came to be, with its clipped lawns, shaped bushes, c...
