Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture.

The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it...

A New Way of Analyzing Object Data from a Nonparametric Viewpoint

Nonparametric Statistics on Manifolds and Their Applications to Object Data Analysis provides one of the first thorough treatments of the theory and methodology for analyzing data on manifolds. It also presents in-depth applications to practical problems arising in a variety of fields, including statistics, medical imaging, computer vision, pattern recognition, and bioinformatics.

The book begins with a survey of illustrative examples of object data before moving to a review of...

The seventh volume in the SemStat series, Statistical Methods for Stochastic Differential Equations presents current research trends and recent developments in statistical methods for stochastic differential equations. Written to be accessible to both new students and seasoned researchers, each self-contained chapter starts with introductions to the topic at hand and builds gradually towards discussing recent research.

The book covers Wiener-driven equations as well as stochastic differential equations with jumps, including continuous-time ARMA processes...

There is a huge amount of literature on statistical models for the prediction of survival after diagnosis of a wide range of diseases like cancer, cardiovascular disease, and chronic kidney disease. Current practice is to use prediction models based on the Cox proportional hazards model and to present those as static models for remaining lifetime after diagnosis or treatment. In contrast, Dynamic Prediction in Clinical Survival Analysis focuses on dynamic models for the remaining lifetime at later points in time, for instance using landmark models.

Designed...

Sequential Analysis: Hypothesis Testing and Changepoint Detection systematically develops the theory of sequential hypothesis testing and quickest changepoint detection. It also describes important applications in which theoretical results can be used efficiently.

The book reviews recent accomplishments in hypothesis testing and changepoint detection both in decision-theoretic (Bayesian) and non-decision-theoretic (non-Bayesian) contexts. The authors not only emphasize traditional binary hypotheses but also substantially more difficult multiple decision...

In multivariate data analysis, regression techniques predict one set of variables from another while principal component analysis (PCA) finds a subspace of minimal dimensionality that captures the largest variability in the data.

• How can regression analysis and PCA be combined in a beneficial way?
• Why and when is it a good idea to combine them?
• What kind of benefits are we getting from them?

Addressing these questions, Constrained Principal Component Analysis and Related Techniques shows how constrained PCA (CPCA) offers a unified...

Written by a prominent statistician and author, the first edition of this bestseller broke new ground in the then emerging subject of spatial statistics with its coverage of spatial point patterns. Retaining all the material from the second edition and adding substantial new material, Statistical Analysis of Spatial and Spatio-Temporal Point Patterns, Third Edition presents models and statistical methods for analyzing spatially referenced point process data.

Reflected in the title, this third edition now covers spatio-temporal point patterns. It explores the...

In the last three decades, there has been a dramatic increase in the use of interacting particle methods as a powerful tool in real-world applications of Monte Carlo simulation in computational physics, population biology, computer sciences, and statistical machine learning. Ideally suited to parallel and distributed computation, these advanced particle algorithms include nonlinear interacting jump diffusions; quantum, diffusion, and resampled Monte Carlo methods; Feynman-Kac particle models; genetic and evolutionary algorithms; sequential Monte Carlo methods; adaptive and interacting...

Bringing together both new and old results, Theory of Factorial Design: Single- and Multi-Stratum Experiments provides a rigorous, systematic, and up-to-date treatment of the theoretical aspects of factorial design. To prepare readers for a general theory, the author first presents a unified treatment of several simple designs, including completely randomized designs, block designs, and row-column designs. As such, the book is accessible to readers with minimal exposure to experimental design. With exercises and numerous examples, it is suitable as a reference for...

Despite research interest in functional data analysis in the last three decades, few books are available on the subject. Filling this gap, Analysis of Variance for Functional Data presents up-to-date hypothesis testing methods for functional data analysis. The book covers the reconstruction of functional observations, functional ANOVA, functional linear models with functional responses, ill-conditioned functional linear models, diagnostics of functional observations, heteroscedastic ANOVA for functional data, and testing equality of covariance functions. Although the...